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Orai1 Gene Detail
Summary
  • Symbol
    Orai1
  • Name
    ORAI calcium release-activated calcium modulator 1
  • Synonyms
    D730049H07Rik, Tmem142a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925542
    NCBI Gene: 109305
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:123153137-123168519 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 62.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    446 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925542
 protein coding gene Chr5:123153078-123168519 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030061
 protein coding gene Chr5:126693879-126709270 (+)
A/J MGP_AJ_G0030026
 protein coding gene Chr5:121435895-121451232 (+)
AKR/J MGP_AKRJ_G0029962
 protein coding gene Chr5:125351670-125366979 (+)
BALB/cJ MGP_BALBcJ_G0030037
 protein coding gene Chr5:122781873-122797727 (+)
C3H/HeJ MGP_C3HHeJ_G0029754
 protein coding gene Chr5:125974594-125993649 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030490
 protein coding gene Chr5:131579004-131595806 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027716
 protein coding gene Chr5:116035444-116049311 (+)
CAST/EiJ MGP_CASTEiJ_G0029163
 protein coding gene Chr5:125072211-125089679 (+)
CBA/J MGP_CBAJ_G0029724
 protein coding gene Chr5:136733117-136755283 (+)
DBA/2J MGP_DBA2J_G0029874
 protein coding gene Chr5:121493944-121509459 (+)
FVB/NJ MGP_FVBNJ_G0029830
 protein coding gene Chr5:120494166-120509716 (+)
LP/J MGP_LPJ_G0029963
 protein coding gene Chr5:127229018-127244294 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029861
 protein coding gene Chr5:140411699-140427327 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030531
 protein coding gene Chr5:124953561-124971070 (+)
PWK/PhJ MGP_PWKPhJ_G0028877
 protein coding gene Chr5:120280315-120295999 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028714
 protein coding gene Chr5:122646119-122661631 (+)
WSB/EiJ MGP_WSBEiJ_G0029238
 protein coding gene Chr5:125620709-125636595 (+)



Homology
more
  • Human Ortholog
    ORAI1, ORAI calcium release-activated calcium modulator 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ORAI1, ORAI calcium release-activated calcium modulator 1
  • Synonyms
    CRACM1, IMD9, ORAT1, TAM2, TMEM142A
  • Links
    NCBI Gene ID: 84876
    neXtProt AC: NX_Q96D31
    UniProt: Q96D31

  • Chr Location
    12q24.31; chr12:121626509-121643218 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human ORAI1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    58 phenotypes from 6 alleles in 9 genetic backgrounds
    14 phenotypes from multigenic genotypes
    75 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit small body size and defects in mast cell degranulation, cytokine secretion, and passive cutaneous anaphylaxis. Male mice are infertile due to a defect in spermatid maturation and show progressive degeneration and atrophy of the seminiferous tubules.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    778
  • Tissues
    51
  • cDNA Data
    33
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049686 Ensembl Gene Model | MGI Sequence Detail 15383 C57BL/6J ±  kb
    transcript ENSMUST00000121652 Ensembl | MGI Sequence Detail 1875 Not Applicable  
    polypeptide ENSMUSP00000113097 Ensembl | MGI Sequence Detail 304 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 33
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 138
      Developmental Gene Expression 4
      Gene Ontology 14
      Phenotypes 75
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:350113 Wei D, et al., PGE2 Potentiates Orai1-Mediated Calcium Entry Contributing to Peripheral Sensitization. J Neurosci. 2024 Jan 3;44(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory