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Cpxm2 Gene Detail
Summary
  • Symbol
    Cpxm2
  • Name
    carboxypeptidase X, M14 family member 2
  • Synonyms
    4632435C11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926006
    NCBI Gene: 55987
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:131634416-131756468 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 75.60 cM, cytoband F4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3753 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926006
 protein coding gene Chr7:131634416-131756483 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033110
 protein coding gene Chr7:136722235-136838641 (-)
A/J MGP_AJ_G0033092
 protein coding gene Chr7:132957619-133071640 (-)
AKR/J MGP_AKRJ_G0033024
 protein coding gene Chr7:136498584-136612202 (-)
BALB/cJ MGP_BALBcJ_G0033093
 protein coding gene Chr7:132642300-132752021 (-)
C3H/HeJ MGP_C3HHeJ_G0032807
 protein coding gene Chr7:136339728-136453001 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033604
 protein coding gene Chr7:141924538-142038474 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030575
 protein coding gene Chr7:134222924-134338963 (-)
CAST/EiJ MGP_CASTEiJ_G0032137
 protein coding gene Chr7:128210897-128320499 (-)
CBA/J MGP_CBAJ_G0032780
 protein coding gene Chr7:146754987-146871613 (-)
DBA/2J MGP_DBA2J_G0032932
 protein coding gene Chr7:130972550-131083282 (-)
FVB/NJ MGP_FVBNJ_G0032885
 protein coding gene Chr7:130798981-130909309 (-)
LP/J MGP_LPJ_G0033026
 protein coding gene Chr7:138204523-138327792 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032917
 protein coding gene Chr7:147718478-147830587 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033624
 protein coding gene Chr7:135488998-135601939 (-)
PWK/PhJ MGP_PWKPhJ_G0031843
 protein coding gene Chr7:123979785-124093172 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031689
 protein coding gene Chr7:122275494-122389335 (-)
WSB/EiJ MGP_WSBEiJ_G0032248
 protein coding gene Chr7:136392964-136505869 (-)



Homology
more
  • Human Ortholog
    CPXM2, carboxypeptidase X, M14 family member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CPXM2, carboxypeptidase X, M14 family member 2
  • Synonyms
    CPX2, UNQ676
  • Links
    NCBI Gene ID: 119587
    neXtProt AC: NX_Q8N436
    UniProt: Q8N436

  • Chr Location
    10q26.13; chr10:123706207-123944104 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display attenuated cardiac responses to induce hypertension.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    2
Molecular Function

Biological Process

Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    749
  • Tissues
    6
  • cDNA Data
    17
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030862 Ensembl Gene Model | MGI Sequence Detail 122053 C57BL/6J ±  kb
    transcript ENSMUST00000033149 Ensembl | MGI Sequence Detail 3498 Not Applicable  
    polypeptide ENSMUSP00000033149 Ensembl | MGI Sequence Detail 764 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000005840 inactive carboxypeptidase-like protein X2
      (term hierarchy)
    • InterPro Domains
      IPR008969 Carboxypeptidase-like, regulatory domain superfamily
      IPR000421 Coagulation factor 5/8 C-terminal domain
      IPR008979 Galactose-binding-like domain superfamily
      IPR000834 Peptidase M14, carboxypeptidase A
      IPR050753 Peptidase M14 domain-containing protein
    • GlyGen
      Q9D2L5 5 sites, 1 N-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 19
      Primer pair 1
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 7
      Gene Ontology 2
      Phenotypes 7
    • Earliest
      J:50715 Xin X, et al., Identification of mouse CPX-2, a novel member of the metallocarboxypeptidase gene family: cDNA cloning, mRNA distribution, and protein expression and characterization. DNA Cell Biol. 1998 Oct;17(10):897-909
    • Latest
      J:345349 Grabowski K, et al., Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension. Hypertens Res. 2022 Feb;45(2):292-307
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory