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E2f5tm1Dli
Targeted Allele Detail
Summary
Symbol: E2f5tm1Dli
Name: E2F transcription factor 5; targeted mutation 1, David M Livingston
MGI ID: MGI:1926192
Synonyms: E2F-5-
Gene: E2f5  Location: Chr3:14643701-14671369 bp, + strand  Genetic Position: Chr3, 3.1 cM
Alliance: E2f5tm1Dli page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47283
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe two exons encoding the carboxy-terminal half of the DNA-binding and the leucine zipper domains were replaced with a neomycin resistance gene. (J:47283)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 12 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any E2f5 Mutation:  13 strains or lines available
References
Original:  J:47283 Lindeman GJ, et al., A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting. Genes Dev. 1998 Apr 15;12(8):1092-8
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory