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Chrnb2tm1Jpc
Targeted Allele Detail
Summary
Symbol: Chrnb2tm1Jpc
Name: cholinergic receptor nicotinic beta 2 subunit; targeted mutation 1, Jean-Pierre Changeux
MGI ID: MGI:1926253
Synonyms: beta2-, beta2-KO
Gene: Chrnb2  Location: Chr3:89660755-89671939 bp, - strand  Genetic Position: Chr3, 39.19 cM
Alliance: Chrnb2tm1Jpc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:23256
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprt1b-m3
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The start codon and the rest of exon 1 was replaced by a lacZ reporter gene and a neomycin resistance gene. (J:23256)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chrnb2 Mutation:  32 strains or lines available
References
Original:  J:23256 Picciotto MR, et al., Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Nature. 1995 Mar 2;374(6517):65-7
All:  87 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory