Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Irf8tm1Hor
Name:	interferon regulatory factor 8; targeted mutation 1, Ivan Horak
MGI ID:	MGI:1926332
Synonyms:	ICSBP-, IRF-8-
Gene:	Irf8  Location: Chr8:121463097-121483433 bp, + strand  Genetic Position: Chr8, 70.05 cM
Alliance:	Irf8tm1Hor page

Germline Transmission:	Earliest citation of germline transmission: J:36038
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A PGK-neomycin gene was inserted into the second exon, disrupting sequences encoding the DNA binding domain. (J:36038)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

List all tumor models in MMHCdb carrying Irf8tm1Hor

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Irf8 Mutation:	35 strains or lines available

Original:	J:36038 Holtschke T, et al., Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell. 1996 Oct 18;87(2):307-17
All:	107 reference(s)