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Ppp2r1a Gene Detail
Summary
  • Symbol
    Ppp2r1a
  • Name
    protein phosphatase 2, regulatory subunit A, alpha
  • Synonyms
    6330556D22Rik, PP2A, PR65, protein phosphatase PP2A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926334
    NCBI Gene: 51792
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:21165716-21186167 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 11.40 cM, cytoband A3.2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    658 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926334
 protein coding gene Chr17:21165573-21186178 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023219
 protein coding gene Chr17:19653529-19674096 (+)
A/J MGP_AJ_G0023186
 protein coding gene Chr17:18862580-18883145 (+)
AKR/J MGP_AKRJ_G0023156
 protein coding gene Chr17:18927321-18947945 (+)
BALB/cJ MGP_BALBcJ_G0023185
 protein coding gene Chr17:19038708-19059275 (+)
C3H/HeJ MGP_C3HHeJ_G0022946
 protein coding gene Chr17:19290307-19310924 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023628
 protein coding gene Chr17:20204757-20225350 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021123
 protein coding gene Chr17:16464850-16484735 (+)
CAST/EiJ MGP_CASTEiJ_G0022459
 protein coding gene Chr17:18958143-18978879 (+)
CBA/J MGP_CBAJ_G0022921
 protein coding gene Chr17:20985145-21005760 (+)
DBA/2J MGP_DBA2J_G0023054
 protein coding gene Chr17:18538419-18558986 (+)
FVB/NJ MGP_FVBNJ_G0023021
 protein coding gene Chr17:18284563-18305231 (+)
LP/J MGP_LPJ_G0023132
 protein coding gene Chr17:19606948-19627515 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023041
 protein coding gene Chr17:20897567-20918158 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023667
 protein coding gene Chr17:19246527-19267094 (+)
PWK/PhJ MGP_PWKPhJ_G0022206
 protein coding gene Chr17:17364416-17382750 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022027
 protein coding gene Chr17:17509455-17530110 (+)
WSB/EiJ MGP_WSBEiJ_G0022519
 protein coding gene Chr17:19415099-19435756 (+)



Homology
more
  • Human Ortholog
    PPP2R1A, protein phosphatase 2 scaffold subunit Aalpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP2R1A, protein phosphatase 2 scaffold subunit Aalpha
  • Synonyms
    HJS2, MRD36, PP2AA, PP2A-Aalpha, PP2AAALPHA, PR65A
  • Links
    NCBI Gene ID: 5518
    neXtProt AC: NX_P30153
    UniProt: P30153

  • Chr Location
    19q13.41; chr19:52170936-52229518 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PPP2R1A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 4 alleles in 5 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele that remove exons 5 and 6 exhibit embryonic lethality. Mice heterozygous for this allele exhibit increased benzopyrene-induced lung tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    939
  • Tissues
    151
  • cDNA Data
    530
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 51792 NCBI Gene Model | MGI Sequence Detail 20452 C57BL/6J ±  kb
    transcript NM_016891 RefSeq | MGI Sequence Detail 2256 C57BL/6  
    polypeptide Q76MZ3 UniProt | EBI | MGI Sequence Detail 589 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 533
      cDNA 530
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1923432
    References
    more
    • Summaries
      All 107
      Developmental Gene Expression 13
      Gene Ontology 18
      Phenotypes 34
    • Earliest
      J:84774 Dunn LC, Studies of the genetic variability in populations of wild house mice. II. Analysis of eight additional alleles at locus T. Genetics. 1957;42:299-311
    • Latest
      J:355261 Rehmani T, et al., SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP. Life Sci Alliance. 2024 Dec;7(12)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory