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Tcf7l2tm1Cle
Targeted Allele Detail
Summary
Symbol: Tcf7l2tm1Cle
Name: transcription factor 7 like 2, T cell specific, HMG box; targeted mutation 1, Hans Clevers
MGI ID: MGI:1926344
Synonyms: Tcf-4-, Tcf4-, Tcf7l2-
Gene: Tcf7l2  Location: Chr19:55730252-55922086 bp, + strand  Genetic Position: Chr19, 51.59 cM
Alliance: Tcf7l2tm1Cle page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:48968
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: Gene disruption caused by insertion of a PGK-hygromycin selection cassette into the exon containing coding sequences for the N-terminal region of the DNA-binding HMG box. (J:48968)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 60 assay results
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcf7l2 Mutation:  58 strains or lines available
References
Original:  J:48968 Korinek V, et al., Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet. 1998 Aug;19(4):379-83
All:  17 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory