Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Tsc2tm1Tno
Name:	TSC complex subunit 2; targeted mutation 1, Tetsuo Noda
MGI ID:	MGI:1926345
Synonyms:	Tsc2-
Gene:	Tsc2  Location: Chr17:24814790-24851604 bp, - strand  Genetic Position: Chr17, 12.41 cM
Alliance:	Tsc2tm1Tno page

Germline Transmission:	Earliest citation of germline transmission: J:52464
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A 3kb genomic fragment that contains part of exon 2, all of exons 3 and 4, and part of exon 5 was replaced by a promoterless NLS-lacZ gene fused in-frame to exon 2, followed by a floxed PGK-neomycin resistance cassette. (J:52464)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

List all tumor models in MMHCdb carrying Tsc2tm1Tno

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tsc2 Mutation:	78 strains or lines available

Original:	J:52464 Kobayashi T, et al., Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice. Cancer Res. 1999 Mar 15;59(6):1206-11
All:	9 reference(s)