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Cdon Gene Detail
Summary
  • Symbol
    Cdon
  • Name
    cell adhesion molecule-related/down-regulated by oncogenes
  • Synonyms
    CAM-related/down-regulated by oncogenes, CDO
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926387
    NCBI Gene: 57810
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:35332836-35418948 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 20.24 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2672 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926387
 protein coding gene Chr9:35332424-35418948 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034535
 protein coding gene Chr9:33231301-33320746 (+)
A/J MGP_AJ_G0034513
 protein coding gene Chr9:32359503-32452701 (+)
AKR/J MGP_AKRJ_G0034439
 protein coding gene Chr9:33097831-33187220 (+)
BALB/cJ MGP_BALBcJ_G0034504
 protein coding gene Chr9:32281592-32374679 (+)
C3H/HeJ MGP_C3HHeJ_G0034216
 protein coding gene Chr9:33430388-33519619 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035025
 protein coding gene Chr9:34329174-34430686 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031955
 protein coding gene Chr9:31052107-31140893 (+)
CAST/EiJ MGP_CASTEiJ_G0033539
 protein coding gene Chr9:33328080-33421707 (+)
CBA/J MGP_CBAJ_G0034190
 protein coding gene Chr9:35492144-35583857 (+)
DBA/2J MGP_DBA2J_G0034347
 protein coding gene Chr9:32348159-32437275 (+)
FVB/NJ MGP_FVBNJ_G0034290
 protein coding gene Chr9:31764939-31854196 (+)
LP/J MGP_LPJ_G0034433
 protein coding gene Chr9:33471365-33564035 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034334
 protein coding gene Chr9:37064435-37156576 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035045
 protein coding gene Chr9:33042603-33135305 (+)
PWK/PhJ MGP_PWKPhJ_G0033244
 protein coding gene Chr9:32331846-32421826 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033079
 protein coding gene Chr9:33197823-33284563 (+)
WSB/EiJ MGP_WSBEiJ_G0033654
 protein coding gene Chr9:32817156-32905606 (+)



Homology
more
  • Human Ortholog
    CDON, cell adhesion associated, oncogene regulated
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDON, cell adhesion associated, oncogene regulated
  • Synonyms
    CDO, CDON1, HPE11, Ihog, ORCAM
  • Links
    NCBI Gene ID: 50937
    neXtProt AC: NX_Q4KMG0
    UniProt: Q4KMG0

  • Chr Location
    11q24.2; chr11:125955796-126063352 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cdon mouse models; 1 with human CDON associations

Human Disease Mouse Models
      
IDs
 View 8 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 4 alleles in 6 genetic backgrounds
    45 phenotypes from multigenic genotypes
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display facial defects characteristic of microform holoprosencephaly, are runted, and are prone to death prior to weaning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1018
  • Tissues
    193
  • cDNA Data
    85
  • Literature Summary
    48
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57810 NCBI Gene Model | MGI Sequence Detail 86113 C57BL/6J ±  kb
    transcript NM_001405246 RefSeq | MGI Sequence Detail 8913 C57BL/6  
    polypeptide Q32MD9 UniProt | EBI | MGI Sequence Detail 1250 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 89
      cDNA 85
      Primer pair 2
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 109
      Developmental Gene Expression 48
      Diseases 2
      Gene Ontology 16
      Phenotypes 49
    • Earliest
      J:65661 Kang JS, et al., CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family. J Cell Biol. 1997 Jul 14;138(1):203-13
    • Latest
      J:351872 Kumari A, et al., Distinct expression patterns of Hedgehog signaling components in mouse gustatory system during postnatal tongue development and adult homeostasis. PLoS One. 2024;19(6):e0294835
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory