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Gab1tm1Thir
Targeted Allele Detail
Summary
Symbol: Gab1tm1Thir
Name: growth factor receptor bound protein 2-associated protein 1; targeted mutation 1, Toshio Hirano
MGI ID: MGI:1926435
Synonyms: Gab1-
Gene: Gab1  Location: Chr8:81491067-81607148 bp, - strand  Genetic Position: Chr8, 38.47 cM, cytoband C3
Alliance: Gab1tm1Thir page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:61790
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A cassette consisting of a splice acceptor site from the mouse En2 gene, an internal ribosomal entry site (IRES), and a beta-galactosidase-neomycin resistance gene fusion replaced 3.0 kb of sequence encoding a part of the pleckstrin homology domain. (J:61790)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 50 assay results
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gab1 Mutation:  78 strains or lines available
References
Original:  J:61790 Itoh M, et al., Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation. Mol Cell Biol. 2000 May;20(10):3695-704
All:  7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory