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Igf1rtm1Arge
Targeted Allele Detail
Summary
Symbol: Igf1rtm1Arge
Name: insulin-like growth factor I receptor; targeted mutation 1, Argiris Efstratiadis
MGI ID: MGI:1926486
Synonyms: Igf1r-, Igf1rn
Gene: Igf1r  Location: Chr7:67602575-67883416 bp, + strand  Genetic Position: Chr7, 37.27 cM
Alliance: Igf1rtm1Arge page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:15108
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Replacement of sequences encoding part of exon 3 with a neomycin resistance gene. (J:15108)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 21 assay results
In Structures Affected by this Mutation: 11 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igf1r Mutation:  88 strains or lines available
References
Original:  J:15108 Liu JP, et al., Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell. 1993 Oct 8;75(1):59-72
All:  31 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory