Tg(ITGA2)1075Fmw Transgene Detail MGI Mouse (MGI:1926489)

Tg(ITGA2)1075Fmw
Transgene Detail

Summary

Symbol:	Tg(ITGA2)1075Fmw
Name:	transgene insertion 1075, Fiona M Watt
MGI ID:	MGI:1926489
Synonyms:	1075 alpha2
Transgene:	Tg(ITGA2)1075Fmw Location: unknown
Alliance:	Tg(ITGA2)1075Fmw page

Transgene
origin

Strain of Origin:

(CBA x C57BL/10)F1

Transgene
description

Transgene Type:

Transgenic (Inserted expressed sequence)

Mutation:

Insertion

Tg(ITGA2)1075Fmw expresses 1 gene

Mutation details: Overexpression of human integrin alpha 2 (ITGA2) in the suprabasal layers of the epidermis driven by the human involucrin (IVL) promoter. 22 copies of this gene were inserted, as determined by southern blotting. (J:30249)

Inheritance:

Not Specified

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

See also Tg(ITGA2)1067Fmw and Tg(ITGA2)1070Fmw for variability in transgene copy number using this construct. Severity of described phenotypes correlates to the copy number of the transgenes.

References

Original:	J:30249 Carroll JM, et al., Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis. Cell. 1995 Dec 15;83(6):957-68
All:	1 reference(s)

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