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P2ry4 Gene Detail
Summary
  • Symbol
    P2ry4
  • Name
    pyrimidinergic receptor P2Y, G-protein coupled, 4
  • Synonyms
    P2Y4, P2Y4R
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926594
    NCBI Gene: 57385
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:99633760-99638475 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 43.72 cM, cytoband C2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    139 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926594
 protein coding gene ChrX:99631964-99638533 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035944
 protein coding gene ChrX:97049647-97054362 (-)
A/J MGP_AJ_G0035929
 protein coding gene ChrX:97093081-97098152 (-)
AKR/J MGP_AKRJ_G0035845
 protein coding gene ChrX:99875931-99880638 (-)
BALB/cJ MGP_BALBcJ_G0035912
 protein coding gene ChrX:95837253-95841960 (-)
C3H/HeJ MGP_C3HHeJ_G0035621
 protein coding gene ChrX:97481666-97486373 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036441
 protein coding gene ChrX:99961419-99966134 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033271
 protein coding gene ChrX:94868290-94873176 (-)
CAST/EiJ MGP_CASTEiJ_G0034908
 protein coding gene ChrX:81784374-81789063 (-)
CBA/J MGP_CBAJ_G0035596
 protein coding gene ChrX:103056716-103061423 (-)
DBA/2J MGP_DBA2J_G0035750
 protein coding gene ChrX:96297820-96302535 (-)
FVB/NJ MGP_FVBNJ_G0035688
 protein coding gene ChrX:95698497-95703204 (-)
LP/J MGP_LPJ_G0035840
 protein coding gene ChrX:98031582-98036297 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035723
 protein coding gene ChrX:107585911-107590742 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036468
 protein coding gene ChrX:96764927-96769634 (-)
PWK/PhJ MGP_PWKPhJ_G0034607
 protein coding gene ChrX:79404343-79409060 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034435
 protein coding gene ChrX:82668660-82673374 (-)
WSB/EiJ MGP_WSBEiJ_G0035047
 protein coding gene ChrX:95482935-95487642 (-)



Homology
more
  • Human Ortholog
    P2RY4, pyrimidinergic receptor P2Y4
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    P2RY4, pyrimidinergic receptor P2Y4
  • Synonyms
    NRU, P2P, P2Y4, UNR
  • Links
    NCBI Gene ID: 5030
    neXtProt AC: NX_P51582
    UniProt: P51582

  • Chr Location
    Xq13.1; chrX:70258166-70260204 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous and hemizygous null mice display abnormal digestive secretion and homozygous null females display partially penetrant lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    5
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044359 Ensembl Gene Model | MGI Sequence Detail 4716 C57BL/6J ±  kb
transcript ENSMUST00000053373 Ensembl | MGI Sequence Detail 4434 Not Applicable  
polypeptide ENSMUSP00000055869 Ensembl | MGI Sequence Detail 361 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 2
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:85117 Lazarowski ER, et al., Cloning and functional characterization of two murine uridine nucleotide receptors reveal a potential target for correcting ion transport deficiency in cystic fibrosis gallbladder. J Pharmacol Exp Ther. 2001 Apr;297(1):43-9
  • Latest
    J:338951 Horckmans M, et al., Loss-of-function N178T variant of the human P2Y(4) receptor is associated with decreased severity of coronary artery disease and improved glucose homeostasis. Front Pharmacol. 2022;13:1049696
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory