Pdgfa<tm1Cbet> Targeted Allele Detail MGI Mouse (MGI:1926817)

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Pdgfa^tm1Cbet
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Pdgfa^tm1Cbet
Name:	platelet derived growth factor, alpha; targeted mutation 1, Christer Betsholtz
MGI ID:	MGI:1926817
Synonyms:	PDGF-A (-)
Gene:	Pdgfa Location: Chr5:138961769-138983125 bp, - strand Genetic Position: Chr5, 77.65 cM
Alliance:	Pdgfa^tm1Cbet page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:33629
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Replacement of exon 4 of Pdgfa gene, which encodes the N-terminal half of the mature Pdgfa chain, with a neomycin cassette. (J:33629)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	61 assay results
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Pdgfa Mutation:	20 strains or lines available

References

Original:	J:33629 Bostrom H, et al., PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell. 1996 Jun 14;85(6):863-73
All:	17 reference(s)

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