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Calcrl Gene Detail
Summary
  • Symbol
    Calcrl
  • Name
    calcitonin receptor-like
  • Synonyms
    CRLR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926944
    NCBI Gene: 54598
  • Alliance
    gene page
  • Transcription Start Sites
    29 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:84160970-84255755 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 49.38 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2287 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926944
 protein coding gene Chr2:84160970-84255786 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025898
 protein coding gene Chr2:84993751-85103173 (-)
A/J MGP_AJ_G0025872
 protein coding gene Chr2:81718907-81816192 (-)
AKR/J MGP_AKRJ_G0025842
 protein coding gene Chr2:83826403-83923917 (-)
BALB/cJ MGP_BALBcJ_G0025869
 protein coding gene Chr2:81851226-81948806 (-)
C3H/HeJ MGP_C3HHeJ_G0025628
 protein coding gene Chr2:84072194-84171846 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026315
 protein coding gene Chr2:87629357-87741227 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023717
 protein coding gene Chr2:78557724-78651427 (-)
CAST/EiJ MGP_CASTEiJ_G0025089
 protein coding gene Chr2:84572115-84675584 (-)
CBA/J MGP_CBAJ_G0025609
 protein coding gene Chr2:90773866-90889642 (-)
DBA/2J MGP_DBA2J_G0025740
 protein coding gene Chr2:81263027-81360636 (-)
FVB/NJ MGP_FVBNJ_G0025703
 protein coding gene Chr2:80498472-80601453 (-)
LP/J MGP_LPJ_G0025828
 protein coding gene Chr2:84808757-84906912 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0026371
 protein coding gene Chr2:84041627-84144901 (-)
PWK/PhJ MGP_PWKPhJ_G0024833
 protein coding gene Chr2:81083089-81185034 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024637
 protein coding gene Chr2:84186094-84294264 (-)
WSB/EiJ MGP_WSBEiJ_G0025159
 protein coding gene Chr2:84717352-84820660 (-)



Homology
more
  • Human Ortholog
    CALCRL, calcitonin receptor like receptor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CALCRL, calcitonin receptor like receptor
  • Synonyms
    CGRPR, CRLR, LMPHM8
  • Links
    NCBI Gene ID: 10203
    neXtProt AC: NX_Q16602
    UniProt: Q16602

  • Chr Location
    2q32.1; chr2:187341964-187448460 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CALCRL associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    2 images
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in lethality between E13.5-E14.5, hydrops fetalis and cardiovascular defects such as thin vascular smooth muscle walls and small, disorganized hearts resulting from a decrease in cell proliferation and an increasein apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    27
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059588 Ensembl Gene Model | MGI Sequence Detail 94786 C57BL/6J ±  kb
    transcript ENSMUST00000074262 Ensembl | MGI Sequence Detail 4882 Not Applicable  
    polypeptide ENSMUSP00000073875 Ensembl | MGI Sequence Detail 463 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000004973 calcitonin gene-related peptide type 1 receptor
      (term hierarchy)
    • InterPro Domains
      IPR003289 GPCR, family 2, calcitonin gene-related peptide, type 1 receptor
      IPR003287 GPCR, family 2, calcitonin receptor family
      IPR001879 GPCR, family 2, extracellular hormone receptor domain
      IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
      IPR017981 GPCR, family 2-like, 7TM
      IPR000832 GPCR, family 2, secretin-like
      IPR017983 GPCR, family 2, secretin-like, conserved site
      IPR050332 G-protein coupled receptor 2
    • GlyGen
      Q9R1W5 6 sites, 3 N-linked glycans (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 27

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2139246
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 8
      Gene Ontology 10
      Phenotypes 27
    • Earliest
      J:30368 Bidegain M, et al., Calcitonin gene-related peptide (CGRP) in the developing mouse limb. Endocr Res. 1995 Nov;21(4):743-55
    • Latest
      J:355019 Kiritoshi T, et al., Cells and circuits for amygdala neuroplasticity in the transition to chronic pain. Cell Rep. 2024 Sep 24;43(9):114669
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory