Cd74<tm1Doi> Targeted Allele Detail MGI Mouse (MGI:1927205)

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Cd74^tm1Doi
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Cd74^tm1Doi
Name:	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); targeted mutation 1, Christophe Benoist and Diane Mathis
MGI ID:	MGI:1927205
Synonyms:	Cd74^tm1Dim, Ii-, Ii⁰
Gene:	Cd74 Location: Chr18:60936921-60945724 bp, + strand Genetic Position: Chr18, 34.41 cM
Alliance:	Cd74^tm1Doi page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:4119
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Replacement of exons 2 and 3 with a neomycin resistance gene. (J:4119)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Cd74 Mutation:	36 strains or lines available

References

Original:	J:4119 Viville S, et al., Mice lacking the MHC class II-associated invariant chain. Cell. 1993 Feb 26;72(4):635-48
All:	32 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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