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Mllt1 Gene Detail
Summary
  • Symbol
    Mllt1
  • Name
    myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1
  • Synonyms
    BAM11, ENL, LTG19
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927238
    NCBI Gene: 64144
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:57199611-57242415 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 29.56 cM, cytoband E1.1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    774 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927238
 protein coding gene Chr17:57199611-57242497 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023943
 protein coding gene Chr17:58630245-58676719 (-)
A/J MGP_AJ_G0023901
 protein coding gene Chr17:57010795-57055261 (-)
AKR/J MGP_AKRJ_G0023870
 protein coding gene Chr17:57731689-57774294 (-)
BALB/cJ MGP_BALBcJ_G0023902
 protein coding gene Chr17:56853384-56896518 (-)
C3H/HeJ MGP_C3HHeJ_G0023666
 protein coding gene Chr17:58451712-58494409 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024348
 protein coding gene Chr17:60888951-60931718 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021794
 protein coding gene Chr17:53484376-53531295 (-)
CAST/EiJ MGP_CASTEiJ_G0023148
 protein coding gene Chr17:58733827-58779288 (-)
CBA/J MGP_CBAJ_G0023642
 protein coding gene Chr17:63277774-63320960 (-)
DBA/2J MGP_DBA2J_G0023770
 protein coding gene Chr17:55708652-55751380 (-)
FVB/NJ MGP_FVBNJ_G0023736
 protein coding gene Chr17:55277723-55321168 (-)
LP/J MGP_LPJ_G0023852
 protein coding gene Chr17:59309974-59353944 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023764
 protein coding gene Chr17:62742847-62785427 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024392
 protein coding gene Chr17:58092802-58137893 (-)
PWK/PhJ MGP_PWKPhJ_G0022894
 protein coding gene Chr17:55074747-55118838 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022705
 protein coding gene Chr17:54855008-54898803 (-)
WSB/EiJ MGP_WSBEiJ_G0023214
 protein coding gene Chr17:58706784-58751057 (-)



Homology
more
  • Human Ortholog
    MLLT1, MLLT1 super elongation complex subunit
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MLLT1, MLLT1 super elongation complex subunit
  • Synonyms
    ENL, LTG19, YEATS1
  • Links
    NCBI Gene ID: 4298
    neXtProt AC: NX_Q03111
    UniProt: Q03111

  • Chr Location
    19p13.3; chr19:6210381-6279975 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a knock-out allele die prior to E8.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    36
  • cDNA Data
    83
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024212 Ensembl Gene Model | MGI Sequence Detail 42805 C57BL/6J ±  kb
transcript ENSMUST00000025053 Ensembl | MGI Sequence Detail 3636 Not Applicable  
polypeptide ENSMUSP00000025053 Ensembl | MGI Sequence Detail 547 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 84
    Genomic 1
    cDNA 83

    Microarray probesets 4
Other
Accession IDs
less
MGI:2146746
References
more
  • Summaries
    All 33
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:65127 Kikuchi Y, et al., Identification and characterization of a molecule, BAM11, that associates with the pleckstrin homology domain of mouse Btk. Int Immunol. 2000 Oct;12(10):1397-408
  • Latest
    J:239715 Galazo MJ, et al., Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity. Neuron. 2016 Jul 06;91(1):90-106
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory