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Rala Gene Detail
Summary
  • Symbol
    Rala
  • Name
    v-ral simian leukemia viral oncogene A (ras related)
  • Synonyms
    3010001O15Rik, Ral, Rasl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927243
    NCBI Gene: 56044
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:18055160-18118802 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 6.05 cM, cytoband A3.1
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1402 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927243
 protein coding gene Chr13:18055156-18118824 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020253
 protein coding gene Chr13:14946112-15008264 (-)
A/J MGP_AJ_G0020210
 protein coding gene Chr13:14763426-14814265 (-)
AKR/J MGP_AKRJ_G0020184
 protein coding gene Chr13:14956736-15011153 (-)
BALB/cJ MGP_BALBcJ_G0020196
 protein coding gene Chr13:14734957-14786513 (-)
C3H/HeJ MGP_C3HHeJ_G0020000
 protein coding gene Chr13:15076038-15130217 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020640
 protein coding gene Chr13:15669453-15726288 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018247
 protein coding gene Chr13:13279676-13330077 (-)
CAST/EiJ MGP_CASTEiJ_G0019534
 protein coding gene Chr13:14775652-14832071 (-)
CBA/J MGP_CBAJ_G0019964
 protein coding gene Chr13:16153036-16216432 (-)
DBA/2J MGP_DBA2J_G0020083
 protein coding gene Chr13:14378049-14428889 (-)
FVB/NJ MGP_FVBNJ_G0020064
 protein coding gene Chr13:14078834-14129959 (-)
LP/J MGP_LPJ_G0020153
 protein coding gene Chr13:15235355-15288934 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020102
 protein coding gene Chr13:16519449-16578301 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020668
 protein coding gene Chr13:14771176-14832775 (-)
PWK/PhJ MGP_PWKPhJ_G0019297
 protein coding gene Chr13:14424911-14476797 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019103
 protein coding gene Chr13:13907238-13959913 (-)
WSB/EiJ MGP_WSBEiJ_G0019594
 protein coding gene Chr13:14791399-14847014 (-)



Homology
more
  • Human Ortholog
    RALA, RAS like proto-oncogene A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RALA, RAS like proto-oncogene A
  • Synonyms
    HINCONS, RAL
  • Links
    NCBI Gene ID: 5898
    neXtProt AC: NX_P11233
    UniProt: P11233

  • Chr Location
    7p14.1; chr7:39623565-39708120 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 4 alleles in 4 genetic backgrounds
    10 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete preweaning lethality and exencephaly.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    67
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    828
  • Tissues
    81
  • cDNA Data
    10
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56044 NCBI Gene Model | MGI Sequence Detail 63643 C57BL/6J ±  kb
    transcript NM_019491 RefSeq | MGI Sequence Detail 2662 ZRU/MplStud  
    polypeptide P63321 UniProt | EBI | MGI Sequence Detail 206 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-13757, MGD-MRK-13771, MGI:1917666, MGI:2145427, MGI:97861
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 5
      Gene Ontology 16
      Phenotypes 24
    • Earliest
      J:10344 Justice MJ, et al., A molecular genetic linkage map of mouse chromosome 13 anchored by the beige (bg) and satin (sa) loci. Genomics. 1990 Feb;6(2):341-51
    • Latest
      J:350444 Martinez-Mayer J, et al., Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Genome Med. 2024 May 31;16(1):75
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory