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Pals2 Gene Detail
Summary
  • Symbol
    Pals2
  • Name
    protein associated with LIN7 2, MAGUK family member
  • Synonyms
    Mpp6, P55t, Pals2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927340
    NCBI Gene: 56524
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:50087221-50175919 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 24.13 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2157 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927340
 protein coding gene Chr6:50087206-50176134 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030727
 protein coding gene Chr6:49198873-49294424 (+)
A/J MGP_AJ_G0030698
 protein coding gene Chr6:46907042-46997876 (+)
AKR/J MGP_AKRJ_G0030623
 protein coding gene Chr6:48560704-48656975 (+)
BALB/cJ MGP_BALBcJ_G0030708
 protein coding gene Chr6:47250051-47339777 (+)
C3H/HeJ MGP_C3HHeJ_G0030421
 protein coding gene Chr6:48584354-48674718 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031163
 protein coding gene Chr6:50309074-50407032 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028370
 protein coding gene Chr6:44518308-44605295 (+)
CAST/EiJ MGP_CASTEiJ_G0029825
 protein coding gene Chr6:48287977-48383247 (+)
CBA/J MGP_CBAJ_G0030396
 protein coding gene Chr6:52421004-52524690 (+)
DBA/2J MGP_DBA2J_G0030545
 protein coding gene Chr6:46817575-46908708 (+)
FVB/NJ MGP_FVBNJ_G0030497
 protein coding gene Chr6:46462536-46548741 (+)
LP/J MGP_LPJ_G0030630
 protein coding gene Chr6:49160474-49251368 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030531
 protein coding gene Chr6:55141506-55240150 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031192
 protein coding gene Chr6:48473504-48569338 (+)
PWK/PhJ MGP_PWKPhJ_G0029537
 protein coding gene Chr6:46383318-46479922 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029373
 protein coding gene Chr6:47802888-47893000 (+)
WSB/EiJ MGP_WSBEiJ_G0029902
 protein coding gene Chr6:48436476-48531485 (+)



Homology
more
  • Human Ortholog
    PALS2, protein associated with LIN7 2, MAGUK p55 family member
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PALS2, protein associated with LIN7 2, MAGUK p55 family member
  • Synonyms
    MPP6, p55T, VAM-1, VAM1
  • Links
    NCBI Gene ID: 51678
    neXtProt AC: NX_Q9NZW5
    UniProt: Q9NZW5

  • Chr Location
    7p15.3; chr7:24573268-24694193 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    4
  • cDNA Data
    9
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038388 Ensembl Gene Model | MGI Sequence Detail 88699 C57BL/6J ±  kb
    transcript ENSMUST00000166318 Ensembl | MGI Sequence Detail 2222 Not Applicable  
    polypeptide ENSMUSP00000125880 Ensembl | MGI Sequence Detail 553 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 2
      cDNA 9
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:6515786
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:32076 Guthridge MA, et al., Induction of expression of growth-related genes by FGF-4 in mouse fibroblasts. Oncogene. 1996 Mar 21;12(6):1267-78
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory