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Sirt2 Gene Detail
Summary
  • Symbol
    Sirt2
  • Name
    sirtuin 2
  • Synonyms
    5730427M03Rik, Sir2l, SIR2L2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927664
    NCBI Gene: 64383
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:28466192-28488086 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 16.92 cM, cytoband B1-2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    644 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927664
 protein coding gene Chr7:28466160-28488086 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031960
 protein coding gene Chr7:27605646-27629756 (+)
A/J MGP_AJ_G0031938
 protein coding gene Chr7:26915295-26937221 (+)
AKR/J MGP_AKRJ_G0031870
 protein coding gene Chr7:27606364-27628296 (+)
BALB/cJ MGP_BALBcJ_G0031945
 protein coding gene Chr7:27073428-27095993 (+)
C3H/HeJ MGP_C3HHeJ_G0031664
 protein coding gene Chr7:27982056-28003954 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032409
 protein coding gene Chr7:28505874-28529391 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029461
 protein coding gene Chr7:27974822-27999654 (+)
CAST/EiJ MGP_CASTEiJ_G0030999
 protein coding gene Chr7:21301806-21325380 (+)
CBA/J MGP_CBAJ_G0031630
 protein coding gene Chr7:29773881-29796266 (+)
DBA/2J MGP_DBA2J_G0031782
 protein coding gene Chr7:26666487-26688369 (+)
FVB/NJ MGP_FVBNJ_G0031739
 protein coding gene Chr7:26745130-26766834 (+)
LP/J MGP_LPJ_G0031862
 protein coding gene Chr7:27926606-27948990 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031775
 protein coding gene Chr7:29245137-29267992 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032439
 protein coding gene Chr7:27084867-27106796 (+)
PWK/PhJ MGP_PWKPhJ_G0030724
 protein coding gene Chr7:21691000-21713857 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030557
 protein coding gene Chr7:18105062-18128906 (+)
WSB/EiJ MGP_WSBEiJ_G0031108
 protein coding gene Chr7:27457008-27479805 (+)



Homology
more
  • Human Ortholog
    SIRT2, sirtuin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIRT2, sirtuin 2
  • Synonyms
    SIR2, SIR2L, SIR2L2
  • Links
    NCBI Gene ID: 22933
    neXtProt AC: NX_Q8IXJ6
    UniProt: Q8IXJ6

  • Chr Location
    19q13.2; chr19:38878555-38899862 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 6 alleles in 9 genetic backgrounds
    7 phenotypes from multigenic genotypes
    4 images
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a floxed allele activated in Schwann cells exhibit delayed myelination during development and following a nerve crush injury. Mice homozygous for a knock-out allele exhibit increased tumor formation and abnormal mitosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    170
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    799
  • Tissues
    24
  • cDNA Data
    10
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 64383 NCBI Gene Model | MGI Sequence Detail 21895 C57BL/6J ±  kb
    transcript NM_022432 RefSeq | MGI Sequence Detail 1843 C57BL/6  
    polypeptide Q8VDQ8 UniProt | EBI | MGI Sequence Detail 389 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 1
      cDNA 10
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1915014
    References
    more
    • Summaries
      All 149
      Developmental Gene Expression 7
      Gene Ontology 25
      Phenotypes 67
    • Earliest
      J:65632 Yang YH, et al., Cloning and characterization of two mouse genes with homology to the yeast sir2 gene. Genomics. 2000 Nov 1;69(3):355-69
    • Latest
      J:354193 Nevoral J, et al., Dynamics and necessity of SIRT1 for maternal-zygotic transition. Sci Rep. 2024 Sep 16;14(1):21598
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory