Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Emx1tm1(cre)Ito
Name:	empty spiracles homeobox 1; targeted mutation 1, Shigeyoshi Itohara
MGI ID:	MGI:1928281
Synonyms:	(Emx1)Cre, Emx1-Cre, Emx1Cre, Emx1Cre, Emx1tm1(cre)Rik
Gene:	Emx1  Location: Chr6:85164913-85181445 bp, + strand  Genetic Position: Chr6, 37.21 cM
Alliance:	Emx1tm1(cre)Ito page

Germline Transmission:	Earliest citation of germline transmission: J:64064
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Emx1tm1(cre)Ito expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Emx1 (MGI:95387)   Mutation details: A cDNA encoding cre recombinase with an N-terminal nuclear localization signal (nls) was inserted immediately before the translation initiation codon in the gene. Under the control of this promoter, Cre activity is detected by embryonic day 12.5; Cre mediated recombination was observed in dorsal telencephalon, neocortex, hippocampus, and olfactory bulb. An Frt flanked Neo cassette was retained in this allele (J:64064)

Activity:	Tissue activity of this recombinase allele
Driver:	Emx1 (mouse) Summary of all recombinase alleles driven by Emx1. Comparative matrix view of recombinase activities Alliance mouse Emx1 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

18 assay results 9 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Emx1 Mutation:	34 strains or lines available

Original:	J:64064 Iwasato T, et al., Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex. Nature. 2000 Aug 17;406(6797):726-31
All:	103 reference(s)