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Grin2atm1Mim
Targeted Allele Detail
Summary
Symbol: Grin2atm1Mim
Name: glutamate receptor, ionotropic, NMDA2A (epsilon 1); targeted mutation 1, Masayoshi Mishina
MGI ID: MGI:1928285
Synonyms: GluRepsilon1, NR2A-, NR2AKO
Gene: Grin2a  Location: Chr16:9385762-9813424 bp, - strand  Genetic Position: Chr16, 5.28 cM
Alliance: Grin2atm1Mim page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:22295
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: Disruption of the exon encoding the M2 and M3 transmembrane regions by insertion of a PGK-neomycin cassette into an Xcm1 site withing the coding region. (J:22295)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grin2a Mutation:  66 strains or lines available
References
Original:  J:22295 Sakimura K, et al., Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit. Nature. 1995 Jan 12;373(6510):151-5
All:  75 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory