Grin2a<tm1Rsp> Targeted Allele Detail MGI Mouse (MGI:1928287)

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Grin2a^tm1Rsp
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Grin2a^tm1Rsp
Name:	glutamate receptor, ionotropic, NMDA2A (epsilon 1); targeted mutation 1, Rolf Sprengel
MGI ID:	MGI:1928287
Synonyms:	NR2A^deltaC
Gene:	Grin2a Location: Chr16:9385762-9813424 bp, - strand Genetic Position: Chr16, 5.28 cM
Alliance:	Grin2a^tm1Rsp page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:45446
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Expression of a receptor lacking the intracellular C-terminal domain by insertion of a PGK-neomycin cassette 3' to the M4 transmembrane coding region, with translation stop codons in three frames. (J:45446)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Grin2a Mutation:	66 strains or lines available

References

Original:	J:45446 Sprengel R, et al., Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. Cell. 1998 Jan 23;92(2):279-89
All:	11 reference(s)

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