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Nrg1tm1Cbm
Targeted Allele Detail
Summary
Symbol: Nrg1tm1Cbm
Name: neuregulin 1; targeted mutation 1, Carmen Birchmeier
MGI ID: MGI:1928489
Synonyms: neuregulindelta7-9, Nrg-
Gene: Nrg1  Location: Chr8:32299493-33381858 bp, - strand  Genetic Position: Chr8, 18.75 cM
Alliance: Nrg1tm1Cbm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:29971
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin resistance gene replaces exons 7, 8 and 9, which encode the carboxy-terminus of the EGF domain of all known Ngf1 variants. (J:29971)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 51 assay results
In Structures Affected by this Mutation: 14 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nrg1 Mutation:  54 strains or lines available
References
Original:  J:29971 Meyer D, et al., Multiple essential functions of neuregulin in development [see comments] [published erratum appears in Nature 1995 Dec 14;378(6558):753]. Nature. 1995 Nov 23;378(6555):386-90
All:  22 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory