Nrg1<tm1Leth> Targeted Allele Detail MGI Mouse (MGI:1928491)

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Nrg1^tm1Leth
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Nrg1^tm1Leth
Name:	neuregulin 1; targeted mutation 1, Lars E Theill
MGI ID:	MGI:1928491
Synonyms:	neuregulin^Ig, Nrg -
Gene:	Nrg1 Location: Chr8:32299493-33381858 bp, - strand Genetic Position: Chr8, 18.75 cM
Alliance:	Nrg1^tm1Leth page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:33038
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Part of exon 3, encoding the Ig domain, was replaced with a PGK-neomycin cassette (J:33038)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Nrg1 Mutation:	54 strains or lines available

References

Original:	J:33038 Kramer R, et al., Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4833-8
All:	6 reference(s)

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