Grin2a<tm1Nak> Targeted Allele Detail MGI Mouse (MGI:1928506)

Grin2a^tm1Nak
Targeted Allele Detail

Summary

Symbol:	Grin2a^tm1Nak
Name:	glutamate receptor, ionotropic, NMDA2A (epsilon 1); targeted mutation 1, Shigetada Nakanishi
MGI ID:	MGI:1928506
Synonyms:	NR2A -, NR2A KO
Gene:	Grin2a Location: Chr16:9385762-9813424 bp, - strand Genetic Position: Chr16, 5.28 cM
Alliance:	Grin2a^tm1Nak page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:66455
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1^c

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: The region spanning the second transmembrane domain was deleted and replaced with a neomycin cassette. (J:66455)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 7 strains available Cell Lines: 0 lines available
Carrying any Grin2a Mutation:	66 strains or lines available

References

Original:	J:66455 Kadotani H, et al., Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit. J Neurosci. 1996 Dec 15;16(24):7859-67
All:	16 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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