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Dpys Gene Detail
Summary
  • Symbol
    Dpys
  • Name
    dihydropyrimidinase
  • Synonyms
    1200017I10Rik, 1300004I01Rik, DHPase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928679
    NCBI Gene: 64705
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:39631883-39720866 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 15.53 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3097 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928679
 protein coding gene Chr15:39631881-39720866 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021817
 protein coding gene Chr15:38219249-38317867 (-)
A/J MGP_AJ_G0021777
 protein coding gene Chr15:36725330-36815727 (-)
AKR/J MGP_AKRJ_G0021758
 protein coding gene Chr15:37821718-37912212 (-)
BALB/cJ MGP_BALBcJ_G0021784
 protein coding gene Chr15:36780766-36874500 (-)
C3H/HeJ MGP_C3HHeJ_G0021558
 protein coding gene Chr15:37744091-37841415 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022223
 protein coding gene Chr15:39671981-39772052 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019760
 protein coding gene Chr15:34486656-34573644 (-)
CAST/EiJ MGP_CASTEiJ_G0021075
 protein coding gene Chr15:38205427-38298871 (-)
CBA/J MGP_CBAJ_G0021527
 protein coding gene Chr15:41094098-41197902 (-)
DBA/2J MGP_DBA2J_G0021651
 protein coding gene Chr15:36574935-36665271 (-)
FVB/NJ MGP_FVBNJ_G0021629
 protein coding gene Chr15:35952726-36044497 (-)
LP/J MGP_LPJ_G0021721
 protein coding gene Chr15:38033971-38128483 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021653
 protein coding gene Chr15:44092068-44185633 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022246
 protein coding gene Chr15:37981689-38085338 (-)
PWK/PhJ MGP_PWKPhJ_G0020820
 protein coding gene Chr15:36626663-36718090 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020657
 protein coding gene Chr15:37658971-37746711 (-)
WSB/EiJ MGP_WSBEiJ_G0021130
 protein coding gene Chr15:37892440-37991687 (-)



Homology
more
  • Human Ortholog
    DPYS, dihydropyrimidinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DPYS, dihydropyrimidinase
  • Synonyms
    DHP, DHPase
  • Links
    NCBI Gene ID: 1807
    neXtProt AC: NX_Q14117
    UniProt: Q14117

  • Chr Location
    8q22.3; chr8:104330324-104467055 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human DPYS associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    28
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022304 Ensembl Gene Model | MGI Sequence Detail 88984 C57BL/6J ±  kb
transcript ENSMUST00000022915 Ensembl | MGI Sequence Detail 2466 Not Applicable  
polypeptide ENSMUSP00000022915 Ensembl | MGI Sequence Detail 519 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 29
    cDNA 28
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1921091, MGI:1924152
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:5178 Sanno Y, et al., Studies of a mutation affecting pyrimidine degradation in inbred mice. J Biol Chem. 1970 Nov 10;245(21):5668-76
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory