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Kcnd3 Gene Detail
Summary
  • Symbol
    Kcnd3
  • Name
    potassium voltage-gated channel, Shal-related family, member 3
  • Synonyms
    Kv4.3, potassium channel Kv4.3L, potassium channel Kv4.3M
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928743
    NCBI Gene: 56543
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:105359646-105581318 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 46.32 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5363 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928743
 protein coding gene Chr3:105359206-105581318 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027717
 protein coding gene Chr3:106816817-107046390 (+)
A/J MGP_AJ_G0027677
 protein coding gene Chr3:103401911-103621872 (+)
AKR/J MGP_AKRJ_G0027642
 protein coding gene Chr3:105968434-106194929 (+)
BALB/cJ MGP_BALBcJ_G0027689
 protein coding gene Chr3:103185232-103406227 (+)
C3H/HeJ MGP_C3HHeJ_G0027419
 protein coding gene Chr3:106310327-106534889 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028133
 protein coding gene Chr3:110813721-111046547 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025473
 protein coding gene Chr3:99480033-99701902 (+)
CAST/EiJ MGP_CASTEiJ_G0026875
 protein coding gene Chr3:105452511-105684929 (+)
CBA/J MGP_CBAJ_G0027394
 protein coding gene Chr3:114544018-114787658 (+)
DBA/2J MGP_DBA2J_G0027536
 protein coding gene Chr3:102637210-102861384 (+)
FVB/NJ MGP_FVBNJ_G0027504
 protein coding gene Chr3:100573641-100794654 (+)
LP/J MGP_LPJ_G0027643
 protein coding gene Chr3:108206353-108448978 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027534
 protein coding gene Chr3:120665011-120903501 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028188
 protein coding gene Chr3:105515529-105744344 (+)
PWK/PhJ MGP_PWKPhJ_G0026601
 protein coding gene Chr3:102419218-102643354 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026422
 protein coding gene Chr3:103547899-103773680 (+)
WSB/EiJ MGP_WSBEiJ_G0026955
 protein coding gene Chr3:106074451-106303557 (+)



Homology
more
  • Human Ortholog
    KCND3, potassium voltage-gated channel subfamily D member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCND3, potassium voltage-gated channel subfamily D member 3
  • Synonyms
    BRGDA9, KCND3L, KCND3S, KSHIVB, KV4.3, SCA19, SCA22
  • Links
    NCBI Gene ID: 3752
    neXtProt AC: NX_Q9UK17
    UniProt: Q9UK17

  • Chr Location
    1p13.2; chr1:111770662-111989668 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human KCND3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter (null) allele are viable and fertile and exhibit normal cardiac morphology and function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    6
  • cDNA Data
    31
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040896 Ensembl Gene Model | MGI Sequence Detail 221673 C57BL/6J ±  kb
    transcript ENSMUST00000118360 Ensembl | MGI Sequence Detail 2668 Not Applicable  
    polypeptide ENSMUSP00000113436 Ensembl | MGI Sequence Detail 655 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000000786 voltage-gated potassium channel KCND3
      (term hierarchy)
    • InterPro Domains
      IPR000210 BTB/POZ domain
      IPR005821 Ion transport domain
      IPR003131 Potassium channel tetramerisation-type BTB domain
      IPR003968 Potassium channel, voltage dependent, Kv
      IPR003975 Potassium channel, voltage dependent, Kv4
      IPR004056 Potassium channel, voltage dependent, Kv4.3
      IPR024587 Potassium channel, voltage dependent, Kv4, C-terminal
      IPR021645 Shal-type voltage-gated potassium channels, N-terminal
      IPR011333 SKP1/BTB/POZ domain superfamily
      IPR027359 Voltage-dependent channel domain superfamily
      IPR028325 Voltage-gated potassium channel
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 31
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2139949
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 15
      Phenotypes 20
    • Earliest
      J:352561 Dixon JE, et al., Role of the Kv4.3 K+ channel in ventricular muscle. A molecular correlate for the transient outward current. Circ Res. 1996 Oct;79(4):659-68
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory