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Nrg1tm1Gne
Targeted Allele Detail
Summary
Symbol: Nrg1tm1Gne
Name: neuregulin 1; targeted mutation 1, Genentech
MGI ID: MGI:1928825
Synonyms: heregulin-, NRG1(deltaEGF)
Gene: Nrg1  Location: Chr8:32299493-33381858 bp, - strand  Genetic Position: Chr8, 18.75 cM
Alliance: Nrg1tm1Gne page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:45302
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Replacement of the exon encoding the N-terminal half of the EGF domain with a neomycin cassette. This null mutation results in disruption of all splice forms of Nrg1. (J:45302)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 14 assay results
In Structures Affected by this Mutation: 11 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nrg1 Mutation:  54 strains or lines available
References
Original:  J:45302 Erickson SL, et al., ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice. Development. 1997 Dec;124(24):4999-5011
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory