Nrg1tm1Lwr
Targeted Allele Detail
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| Symbol: |
Nrg1tm1Lwr |
| Name: |
neuregulin 1; targeted mutation 1, Lorna W Role |
| MGI ID: |
MGI:1928831 |
| Synonyms: |
CRD-NRG-1-, Nrg1Lwrtm1, Nrg1tm1.1Lwr, Type III Nrg1- |
| Gene: |
Nrg1 Location: Chr8:32299493-33381858 bp, - strand Genetic Position: Chr8, 18.75 cM
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| Alliance: |
Nrg1tm1Lwr page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:60159
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
129
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutation: |
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Insertion
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Mutation details: The cysteine-rich domain (CRD) in the alternatively spliced N-terminus was disrupted by the creation of a nonsense mutation and an Xba1 site in the exon encoding the CRD. A loxP site flanked neomycin resistance gene cassette was inserted into the intron following the CRD-encoding exon.
(J:60159)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Nrg1 Mutation: |
54 strains or lines available
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| Original: |
J:60159 Wolpowitz D, et al., Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses. Neuron. 2000 Jan;25(1):79-91 |
| All: |
28 reference(s) |
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Analysis Tools
