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Mocs1 Gene Detail
Summary
  • Symbol
    Mocs1
  • Name
    molybdenum cofactor synthesis 1
  • Synonyms
    3110045D15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928904
    NCBI Gene: 56738
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:49735390-49762463 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 25.45 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    589 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928904
 protein coding gene Chr17:49735378-49762463 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023877
 protein coding gene Chr17:50802270-50823198 (+)
A/J MGP_AJ_G0023837
 protein coding gene Chr17:49428465-49449782 (+)
AKR/J MGP_AKRJ_G0023805
 protein coding gene Chr17:49956127-49977485 (+)
BALB/cJ MGP_BALBcJ_G0023839
 protein coding gene Chr17:49347159-49366995 (+)
C3H/HeJ MGP_C3HHeJ_G0023602
 protein coding gene Chr17:50646455-50666856 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024282
 protein coding gene Chr17:52900033-52924357 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021731
 protein coding gene Chr17:46169968-46190173 (+)
CAST/EiJ MGP_CASTEiJ_G0023084
 protein coding gene Chr17:50864288-50884989 (+)
CBA/J MGP_CBAJ_G0023578
 protein coding gene Chr17:54822926-54844159 (+)
DBA/2J MGP_DBA2J_G0023707
 protein coding gene Chr17:48190006-48209635 (+)
FVB/NJ MGP_FVBNJ_G0023673
 protein coding gene Chr17:47866734-47888687 (+)
LP/J MGP_LPJ_G0023787
 protein coding gene Chr17:51524885-51546444 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023701
 protein coding gene Chr17:54233644-54252825 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024328
 protein coding gene Chr17:50290356-50311622 (+)
PWK/PhJ MGP_PWKPhJ_G0022829
 protein coding gene Chr17:47644410-47664277 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022643
 protein coding gene Chr17:47208668-47228843 (+)
WSB/EiJ MGP_WSBEiJ_G0023148
 protein coding gene Chr17:50882695-50903520 (+)



Homology
more
  • Human Ortholog
    MOCS1, molybdenum cofactor synthesis 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MOCS1, molybdenum cofactor synthesis 1
  • Synonyms
    MIG11, MOCOD, MOCS1A, MOCS1B
  • Links
    NCBI Gene ID: 4337
    neXtProt AC: NX_Q9NZB8
    UniProt: Q9NZB8

  • Chr Location
    6p21.2; chr6:39899578-39934551 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mocs1 mouse models; 1 with human MOCS1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation lack the cofactor molybdopterin and enzyme activities dependent on the cofactor (including sulfate oxidase and xanthine oxidase), have curly whiskers, and die between postnatal days 1 and 11.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    42
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000064120 Ensembl Gene Model | MGI Sequence Detail 27074 C57BL/6J ±  kb
    transcript ENSMUST00000173033 Ensembl | MGI Sequence Detail 2588 Not Applicable  
    polypeptide ENSMUSP00000133694 Ensembl | MGI Sequence Detail 636 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000010512 molybdenum cofactor biosynthesis protein 1
      (term hierarchy)
    • EC
      4.1.99.22, 4.6.1.17
    • InterPro Domains
      IPR013785 Aldolase-type TIM barrel
      IPR006638 Elp3/MiaA/NifB-like, radical SAM core domain
      IPR000385 MoaA/NifB/PqqE, iron-sulphur binding, conserved site
      IPR023045 Molybdenum cofactor biosynthesis C
      IPR047594 Molybdenum cofactor biosynthesis C, bacteria/eukaryotes
      IPR050105 Molybdenum cofactor biosynthesis MoaA/MoaC
      IPR013483 Molybdenum cofactor biosynthesis protein A
      IPR010505 Molybdenum cofactor biosynthesis protein A-like, twitch domain
      IPR002820 Molybdopterin cofactor biosynthesis C (MoaC) domain
      IPR036522 Molybdopterin cofactor biosynthesis C (MoaC) domain superfamily
      IPR007197 Radical SAM
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 42

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1920445, MGI:2146791, MGI:2147069
    References
    more
    • Summaries
      All 35
      Diseases 1
      Gene Ontology 9
      Phenotypes 5
    • Earliest
      J:66677 Gray TA, et al., Diverse splicing mechanisms fuse the evolutionarily conserved bicistronic MOCS1A and MOCS1B open reading frames. RNA. 2000 Jul;6(7):928-36
    • Latest
      J:336818 Mayr SJ, et al., Alternative splicing of the bicistronic gene molybdenum cofactor synthesis 1 (MOCS1) uncovers a novel mitochondrial protein maturation mechanism. J Biol Chem. 2020 Mar 6;295(10):3029-3039
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory