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Supt20 Gene Detail
Summary
  • Symbol
    Supt20
  • Name
    SPT20 SAGA complex component
  • Synonyms
    D3Ertd300e, Fam48a, p38 interacting protein, p38IP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929651
    NCBI Gene: 56790
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:54600228-54636187 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 25.59 cM, cytoband D
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    856 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929651
 protein coding gene Chr3:54600181-54636187 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027212
 protein coding gene Chr3:53389587-53429021 (+)
A/J MGP_AJ_G0027172
 protein coding gene Chr3:51746401-51784664 (+)
AKR/J MGP_AKRJ_G0027142
 protein coding gene Chr3:52805858-52843433 (+)
BALB/cJ MGP_BALBcJ_G0027185
 protein coding gene Chr3:51600242-51636080 (+)
C3H/HeJ MGP_C3HHeJ_G0026928
 protein coding gene Chr3:53017910-53055705 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027631
 protein coding gene Chr3:55427299-55465095 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024990
 protein coding gene Chr3:48271429-48306029 (+)
CAST/EiJ MGP_CASTEiJ_G0026380
 protein coding gene Chr3:53155410-53192540 (+)
CBA/J MGP_CBAJ_G0026904
 protein coding gene Chr3:57196561-57234975 (+)
DBA/2J MGP_DBA2J_G0027038
 protein coding gene Chr3:51308670-51344477 (+)
FVB/NJ MGP_FVBNJ_G0027006
 protein coding gene Chr3:50279880-50315842 (+)
LP/J MGP_LPJ_G0027150
 protein coding gene Chr3:54095059-54132579 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027024
 protein coding gene Chr3:61302724-61342067 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027689
 protein coding gene Chr3:52724356-52762252 (+)
PWK/PhJ MGP_PWKPhJ_G0026112
 protein coding gene Chr3:50983160-51018908 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025925
 protein coding gene Chr3:52483533-52521136 (+)
WSB/EiJ MGP_WSBEiJ_G0026454
 protein coding gene Chr3:52855615-52892183 (+)



Homology
more
  • Human Ortholog
    SUPT20H, SPT20 homolog, SAGA complex component
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SUPT20H, SPT20 homolog, SAGA complex component
  • Synonyms
    C13, C13orf19, FAM48A, FP757, P38IP, SPT20
  • Links
    NCBI Gene ID: 55578
    neXtProt AC: NX_Q8NEM7
    UniProt: Q8NEM7

  • Chr Location
    13q13.3; chr13:37009312-37059713 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
The incompletely penetrant homozygous phenotype of a splice-site mutation may include retinal epithelium expansion over the dorsal half of the eye, exencephaly, spina bifida, gastrulation defects and/or aberrant somite and mesoderm development. A few mutants survive postnatally and appear normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    6
  • cDNA Data
    14
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027751 Ensembl Gene Model | MGI Sequence Detail 35960 C57BL/6J ±  kb
    transcript ENSMUST00000197502 Ensembl | MGI Sequence Detail 2751 Not Applicable  
    polypeptide ENSMUSP00000143750 Ensembl | MGI Sequence Detail 784 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 15
      Primer pair 1
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1196291, MGI:2139717, MGI:3034561
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory