Nampt MGI Mouse Gene Detail - MGI:1929865 - nicotinamide phosphoribosyltransferase

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Nampt Gene Detail

Symbol

Nampt
Name

nicotinamide phosphoribosyltransferase
Synonyms

1110035O14Rik, Pbef1, Visfatin

Feature Type

protein coding gene
IDs

MGI:1929865
NCBI Gene: 59027
Alliance

gene page
Transcription Start Sites

28 TSS

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Sequence Map

Chr12:32870334-32903368 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 13.74 cM, cytoband B1
Mapping Data

3 experiments

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SNPs within 2kb

920 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1929865	protein coding gene	Chr12:32869544-32903368 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019671	protein coding gene	Chr12:30852511-30891954 (+)
A/J	MGP_AJ_G0019638	protein coding gene	Chr12:29936406-29969335 (+)
AKR/J	MGP_AKRJ_G0019609	protein coding gene	Chr12:30911882-30946114 (+)
BALB/cJ	MGP_BALBcJ_G0019615	protein coding gene	Chr12:30158063-30195450 (+)
C3H/HeJ	MGP_C3HHeJ_G0019419	protein coding gene	Chr12:30764662-30797070 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020062	protein coding gene	Chr12:31782704-31816635 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017687	protein coding gene	Chr12:29235147-29269583 (+)
CAST/EiJ	MGP_CASTEiJ_G0018974	protein coding gene	Chr12:25797008-25831189 (+)
CBA/J	MGP_CBAJ_G0019391	protein coding gene	Chr12:32803193-32837400 (+)
DBA/2J	MGP_DBA2J_G0019504	protein coding gene	Chr12:29764823-29798437 (+)
FVB/NJ	MGP_FVBNJ_G0019495	protein coding gene	Chr12:29549328-29582843 (+)
LP/J	MGP_LPJ_G0019574	protein coding gene	Chr12:30935061-30974387 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019530	protein coding gene	Chr12:32433023-32474331 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020102	protein coding gene	Chr12:30417464-30450529 (+)
PWK/PhJ	MGP_PWKPhJ_G0018741	protein coding gene	Chr12:24524746-24557580 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018529	protein coding gene	Chr12:25028277-25060704 (+)
WSB/EiJ	MGP_WSBEiJ_G0019024	protein coding gene	Chr12:30657614-30692286 (+)

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Human Ortholog

NAMPT, nicotinamide phosphoribosyltransferase

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NAMPT, nicotinamide phosphoribosyltransferase
Synonyms

1110035O14Rik, PBEF, PBEF1, VF, VISFATIN
Links

HGNC:30092

NCBI Gene ID: 10135

neXtProt AC: NX_P43490

UniProt: P43490
Chr Location

7q22.3; chr7:106248298-106285966 (-) GRCh38

MGI Vertebrate Homology

Nampt stringent orthology
1 human;1 mouse;1 rat;4 zebrafish
HCOP

vertebrate homology predictions: NAMPT
Protein SuperFamily

NMPRT
Gene Tree

Nampt

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Diseases

1 with human NAMPT associations

				Human Disease	Mouse Models
				transient cerebral ischemia IDs transient cerebral ischemia DOID:224 DOID:2315 ICD10CM:G45.9 ICD9CM:435.8 MESH:D002546 NCI:C50781 UMLS_CUI:C0007787

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

28 phenotypes from 4 alleles in 6 genetic backgrounds
53 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

61
Endonuclease-mediated

5
Gene trapped

49
Targeted

7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

93 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit embryonic lethality prior to E10.5. Mice heterozygous for a null allele exhibit increased fasted glucose in male mice and impaired glucose tolerance and decresed glucose-stimulated insulin secretion in female mice.

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All GO Annotations

33
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

957
Tissues

173
cDNA Data

173
Literature Summary

8

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nampt

ZFIN nampt1, nampt2

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All Sequences

46
RefSeq

2
UniProt

3
CCDS

CCDS25871.1

Ensembl

ENSMUSG00000020572 (Evidence)
NCBI Gene

59027

Representative Sequences				Length	Strain/Species	Flank
	genomic	59027	NCBI Gene Model \| MGI Sequence Detail	33035	C57BL/6J	± kb
	transcript	NM_021524	RefSeq \| MGI Sequence Detail	4547	C57BL/6
	polypeptide	Q99KQ4	UniProt \| EBI \| MGI Sequence Detail	491	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010967 nicotinamide phosphoribosyltransferase

(term hierarchy)
PDB

2GVL, 2H3B, 2H3D, 7Q8T
EC

2.4.2.12
InterPro Domains

IPR013785 Aldolase-type TIM barrel

IPR016471 Nicotinamide phosphoribosyl transferase

IPR041529 Nicotinamide phosphoribosyltransferase, N-terminal domain

IPR041525 Nicotinate/nicotinamide phosphoribosyltransferase

IPR036068 Nicotinate phosphoribosyltransferase-like, C-terminal
GlyGen

Q99KQ4 1 site, 1 O-linked glycan (1 site)

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All nucleic 173

cDNA 173

Microarray probesets 4

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MGI:1915933, MGI:2144781, MGI:2144846

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Summaries

All 125

Developmental Gene Expression 8

Gene Ontology 11

Phenotypes 53
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:356539 Qi N, et al., Adipocyte-specific inactivation of NAMPT, a key NAD(+) biosynthetic enzyme, causes a metabolically unhealthy lean phenotype in female mice during aging. Am J Physiol Endocrinol Metab. 2024 Jul 1;327(1):E81-E88

TSS for Nampt:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113139	Chr12:32869636-32869648 (+)	-692 bp
Tssr113140	Chr12:32870230-32870244 (+)	-97 bp
Tssr113141	Chr12:32870303-32870361 (+)	-2 bp
Tssr113142	Chr12:32870364-32870380 (+)	38 bp
Tssr113143	Chr12:32870436-32870485 (+)	127 bp
Tssr113144	Chr12:32870496-32870518 (+)	173 bp
Tssr113145	Chr12:32870529-32870540 (+)	201 bp
Tssr113146	Chr12:32870767-32870809 (+)	454 bp
Tssr113147	Chr12:32870810-32870827 (+)	485 bp
Tssr113148	Chr12:32871316-32871333 (+)	991 bp
Tssr113149	Chr12:32871624-32871628 (+)	1,292 bp
Tssr113150	Chr12:32880138-32880149 (+)	9,810 bp
Tssr113151	Chr12:32880259-32880281 (+)	9,936 bp
Tssr113152	Chr12:32881996-32882013 (+)	11,671 bp
Tssr113153	Chr12:32884352-32884391 (+)	14,038 bp
Tssr113154	Chr12:32885390-32885393 (+)	15,058 bp
Tssr113155	Chr12:32889234-32889246 (+)	18,906 bp
Tssr113156	Chr12:32890935-32890948 (+)	20,608 bp
Tssr113157	Chr12:32891050-32891062 (+)	20,722 bp
Tssr113158	Chr12:32898610-32898625 (+)	28,284 bp
Tssr113159	Chr12:32898665-32898684 (+)	28,341 bp
Tssr113160	Chr12:32900508-32900575 (+)	30,208 bp
Tssr113161	Chr12:32900578-32900607 (+)	30,259 bp
Tssr113162	Chr12:32900631-32900655 (+)	30,309 bp
Tssr113163	Chr12:32900672-32900690 (+)	30,347 bp
Tssr113164	Chr12:32900703-32900727 (+)	30,381 bp
Tssr113165	Chr12:32900779-32900799 (+)	30,455 bp
Tssr113166	Chr12:32901432-32901443 (+)	31,104 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24