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Trem1 Gene Detail
Summary
  • Symbol
    Trem1
  • Name
    triggering receptor expressed on myeloid cells 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930005
    NCBI Gene: 58217
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:48539796-48553952 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 23.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    638 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930005
 protein coding gene Chr17:48539763-48553955 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023864
 protein coding gene Chr17:49500947-49515074 (+)
A/J MGP_AJ_G0023824
 protein coding gene Chr17:48206618-48220775 (+)
AKR/J MGP_AKRJ_G0023792
 protein coding gene Chr17:48680379-48694528 (+)
BALB/cJ MGP_BALBcJ_G0023826
 protein coding gene Chr17:48133910-48148057 (+)
C3H/HeJ MGP_C3HHeJ_G0023589
 protein coding gene Chr17:49387464-49401617 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024269
 protein coding gene Chr17:51605356-51619499 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021718
 protein coding gene Chr17:44974847-44984915 (+)
CAST/EiJ MGP_CASTEiJ_G0023071
 protein coding gene Chr17:49570082-49584353 (+)
CBA/J MGP_CBAJ_G0023565
 protein coding gene Chr17:53449015-53463168 (+)
DBA/2J MGP_DBA2J_G0023694
 protein coding gene Chr17:46978051-46992200 (+)
FVB/NJ MGP_FVBNJ_G0023660
 protein coding gene Chr17:46638386-46652546 (+)
LP/J MGP_LPJ_G0023774
 protein coding gene Chr17:50209692-50223834 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023688
 protein coding gene Chr17:52946842-52960998 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024315
 protein coding gene Chr17:49020085-49034241 (+)
PWK/PhJ MGP_PWKPhJ_G0022816
 protein coding gene Chr17:46400691-46414946 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022630
 protein coding gene Chr17:45914481-45928999 (+)
WSB/EiJ MGP_WSBEiJ_G0023135
 protein coding gene Chr17:49605292-49619422 (+)



Homology
more
  • Human Ortholog
    TREM1, triggering receptor expressed on myeloid cells 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TREM1, triggering receptor expressed on myeloid cells 1
  • Synonyms
    CD354, TREM-1
  • Links
    NCBI Gene ID: 54210
    neXtProt AC: NX_Q9NP99
    UniProt: Q9NP99

  • Chr Location
    6p21.1; chr6:41267385-41286682 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TREM1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele exhibit decreased susceptibility to DEN induced tumors and liver damage. Mice homozygous for a knock-out allele of Trem1 and Trem3 exhibit increased susceptibility to P. aeruginosa infection with reduced neutrophil transepithelial migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    15
  • cDNA Data
    7
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042265 Ensembl Gene Model | MGI Sequence Detail 14157 C57BL/6J ±  kb
transcript ENSMUST00000048782 Ensembl | MGI Sequence Detail 2993 Not Applicable  
polypeptide ENSMUSP00000038636 Ensembl | MGI Sequence Detail 230 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 3
References
more
  • Summaries
    All 92
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 45
  • Earliest
    J:64954 Bouchon A, et al., Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol. 2000 May 15;164(10):4991-5
  • Latest
    J:351194 Zhou M, et al., BMAL2 promotes eCIRP-induced macrophage endotoxin tolerance. Front Immunol. 2024;15:1426682
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory