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Dnajb5 Gene Detail
Summary
  • Symbol
    Dnajb5
  • Name
    DnaJ heat shock protein family (Hsp40) member B5
  • Synonyms
    1110058L06Rik, Hsc40, Hsp40-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930018
    NCBI Gene: 56323
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:42949866-42959425 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 22.93 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    268 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930018
 protein coding gene Chr4:42949814-42959425 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028194
 protein coding gene Chr4:41022744-41032921 (+)
A/J MGP_AJ_G0028150
 protein coding gene Chr4:39588312-39597177 (+)
AKR/J MGP_AKRJ_G0028102
 protein coding gene Chr4:40484907-40493732 (+)
BALB/cJ MGP_BALBcJ_G0028170
 protein coding gene Chr4:39675193-39684363 (+)
C3H/HeJ MGP_C3HHeJ_G0027892
 protein coding gene Chr4:41113732-41122597 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028611
 protein coding gene Chr4:42555897-42564781 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025923
 protein coding gene Chr4:37050272-37060336 (+)
CAST/EiJ MGP_CASTEiJ_G0027332
 protein coding gene Chr4:40584617-40596725 (+)
CBA/J MGP_CBAJ_G0027858
 protein coding gene Chr4:43891030-43899908 (+)
DBA/2J MGP_DBA2J_G0028007
 protein coding gene Chr4:39497997-39507267 (+)
FVB/NJ MGP_FVBNJ_G0027974
 protein coding gene Chr4:38725144-38733995 (+)
LP/J MGP_LPJ_G0028106
 protein coding gene Chr4:41095653-41104490 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027998
 protein coding gene Chr4:47149210-47158037 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028647
 protein coding gene Chr4:40683320-40692165 (+)
PWK/PhJ MGP_PWKPhJ_G0027058
 protein coding gene Chr4:39536381-39545639 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026884
 protein coding gene Chr4:40236504-40246781 (+)
WSB/EiJ MGP_WSBEiJ_G0027412
 protein coding gene Chr4:40589820-40600250 (+)



Homology
more
  • Human Ortholog
    DNAJB5, DnaJ heat shock protein family (Hsp40) member B5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNAJB5, DnaJ heat shock protein family (Hsp40) member B5
  • Synonyms
    Hsc40
  • Links
    NCBI Gene ID: 25822
    neXtProt AC: NX_O75953
    UniProt: O75953

  • Chr Location
    9p13.3; chr9:34989641-34998900 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    963
  • Tissues
    58
  • cDNA Data
    25
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 56323 NCBI Gene Model | MGI Sequence Detail 9560 C57BL/6J ±  kb
transcript NM_001355438 RefSeq | MGI Sequence Detail 3535 C57BL/6  
polypeptide O89114 UniProt | EBI | MGI Sequence Detail 348 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    cDNA 25

    Microarray probesets 5
Other
Accession IDs
less
MGI:1916009, MGI:2140298
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:58146 Chen MS, et al., Hsc40, a new member of the hsp40 family, exhibits similar expression profile to that of hsc70 in mammalian cells. Gene. 1999 Oct 1;238(2):333-41
  • Latest
    J:346667 San Gil R, et al., A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration. Nat Commun. 2024 Feb 19;15(1):1508
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory