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Pmaip1 Gene Detail
Summary
  • Symbol
    Pmaip1
  • Name
    phorbol-12-myristate-13-acetate-induced protein 1
  • Synonyms
    Noxa
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930146
    NCBI Gene: 58801
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:66591675-66598629 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 39.52 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    307 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930146
 protein coding gene Chr18:66591604-66598636 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024517
 protein coding gene Chr18:66689358-66696304 (+)
A/J MGP_AJ_G0024484
 protein coding gene Chr18:63767382-63774328 (+)
AKR/J MGP_AKRJ_G0024454
 protein coding gene Chr18:65608076-65615022 (+)
BALB/cJ MGP_BALBcJ_G0024483
 protein coding gene Chr18:63918630-63925576 (+)
C3H/HeJ MGP_C3HHeJ_G0024251
 protein coding gene Chr18:65792698-65799644 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024930
 protein coding gene Chr18:68442123-68449069 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022361
 protein coding gene Chr18:63192852-63199912 (+)
CAST/EiJ MGP_CASTEiJ_G0023724
 protein coding gene Chr18:65803745-65810721 (+)
CBA/J MGP_CBAJ_G0024221
 protein coding gene Chr18:70765154-70772100 (+)
DBA/2J MGP_DBA2J_G0024351
 protein coding gene Chr18:63437325-63444271 (+)
FVB/NJ MGP_FVBNJ_G0024317
 protein coding gene Chr18:62807488-62814434 (+)
LP/J MGP_LPJ_G0024435
 protein coding gene Chr18:66535934-66542880 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024346
 protein coding gene Chr18:72075683-72082629 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024977
 protein coding gene Chr18:65810123-65817069 (+)
PWK/PhJ MGP_PWKPhJ_G0023467
 protein coding gene Chr18:63697657-63704618 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023272
 protein coding gene Chr18:65968926-65975914 (+)
WSB/EiJ MGP_WSBEiJ_G0023788
 protein coding gene Chr18:65656049-65663889 (+)



Homology
more
  • Human Ortholog
    PMAIP1, phorbol-12-myristate-13-acetate-induced protein 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PMAIP1, phorbol-12-myristate-13-acetate-induced protein 1
  • Synonyms
    APR, NOXA
  • Links
    NCBI Gene ID: 5366
    neXtProt AC: NX_Q13794
    UniProt: Q13794

  • Chr Location
    18q21.32; chr18:59899996-59904305 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Though inactivation of this gene results in apoptotic abnormalities, homozygous null mice develop normally and show no evidence of tumorigenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    803
  • Tissues
    42
  • cDNA Data
    30
  • Literature Summary
    41
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 58801 NCBI Gene Model | MGI Sequence Detail 6955 C57BL/6J ±  kb
transcript NM_021451 RefSeq | MGI Sequence Detail 2654 C57BL/6  
polypeptide Q9JM54 UniProt | EBI | MGI Sequence Detail 103 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 41
    cDNA 30
    Primer pair 9
    Other 2

    Microarray probesets 3
References
more
  • Summaries
    All 139
    Developmental Gene Expression 41
    Gene Ontology 19
    Phenotypes 50
  • Earliest
    J:62057 Oda E, et al., Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science. 2000 May 12;288(5468):1053-8
  • Latest
    J:352165 Lin Y, et al., Denticleless E3 ubiquitin protein ligase (DTL) maintains the proliferation and differentiation of epidermis and hair follicles during skin development. Dev Dyn. 2024 Jul;253(7):635-647
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory