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Myh10 Gene Detail
Summary
  • Symbol
    Myh10
  • Name
    myosin, heavy polypeptide 10, non-muscle
  • Synonyms
    5730504C04Rik, 9330167F11Rik, Fltn, Fltn, mKIAA3005, Myhn-2, Myhn2, myosin IIB, Myosin IIB, NMHC-B, NMHC II-B, nonmuscle myosin heavy chain II-B, nonmuscle myosin heavy chain IIB, SMemb
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930780
    NCBI Gene: 77579
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:68582385-68707458 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 41.95 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3331 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930780
 protein coding gene Chr11:68581228-68707458 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018504
 protein coding gene Chr11:69058860-69189956 (+)
A/J MGP_AJ_G0018473
 protein coding gene Chr11:66472527-66601863 (+)
AKR/J MGP_AKRJ_G0018442
 protein coding gene Chr11:68456598-68587102 (+)
BALB/cJ MGP_BALBcJ_G0018444
 protein coding gene Chr11:66759660-66887632 (+)
C3H/HeJ MGP_C3HHeJ_G0018257
 protein coding gene Chr11:68479951-68607314 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018896
 protein coding gene Chr11:71155485-71290224 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016540
 protein coding gene Chr11:63415734-63544822 (+)
CAST/EiJ MGP_CASTEiJ_G0017813
 protein coding gene Chr11:68712359-68842948 (+)
CBA/J MGP_CBAJ_G0018231
 protein coding gene Chr11:74317511-74454332 (+)
DBA/2J MGP_DBA2J_G0018340
 protein coding gene Chr11:66068974-66198779 (+)
FVB/NJ MGP_FVBNJ_G0018330
 protein coding gene Chr11:65691701-65820935 (+)
LP/J MGP_LPJ_G0018411
 protein coding gene Chr11:69633333-69766922 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018353
 protein coding gene Chr11:75012747-75144938 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018937
 protein coding gene Chr11:68700679-68831349 (+)
PWK/PhJ MGP_PWKPhJ_G0017588
 protein coding gene Chr11:66696543-66825342 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017376
 protein coding gene Chr11:68534834-68664426 (+)
WSB/EiJ MGP_WSBEiJ_G0017866
 protein coding gene Chr11:68333832-68467176 (+)



Homology
more
  • Human Ortholog
    MYH10, myosin heavy chain 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYH10, myosin heavy chain 10
  • Synonyms
    NMMHCB, NMMHC-IIB
  • Links
    NCBI Gene ID: 4628
    neXtProt AC: NX_P35580
    UniProt: P35580

  • Chr Location
    17p13.1; chr17:8474207-8631376 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    124 phenotypes from 11 alleles in 15 genetic backgrounds
    24 phenotypes from multigenic genotypes
    27 images
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice show pre- and neonatal death, heart defects and hydrocephaly. Deletion of exon B1 disrupts migration of facial neurons, whereas deletion of exon B2 leads to Purkinje cell anomalies. Hypomorphs show hydrocephaly and defects in motor control, cerebellar foliation and neuron migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    107
  • GO References
    29
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1299
  • Tissues
    96
  • cDNA Data
    18
  • Literature Summary
    79
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020900 Ensembl Gene Model | MGI Sequence Detail 125074 C57BL/6J ±  kb
    transcript ENSMUST00000092984 Ensembl | MGI Sequence Detail 7759 Not Applicable  
    polypeptide ENSMUSP00000090661 Ensembl | MGI Sequence Detail 2013 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 2
      cDNA 18
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12746, MGD-MRK-12750, MGI:1344335, MGI:1924454, MGI:1924829, MGI:97258
    References
    more
    • Summaries
      All 200
      Developmental Gene Expression 79
      Gene Ontology 29
      Phenotypes 67
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:351096 Chen X, et al., Styxl2 regulates de novo sarcomere assembly by binding to non-muscle myosin IIs and promoting their degradation. Elife. 2024 Jun 3;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory