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Osr2 Gene Detail
Summary
  • Symbol
    Osr2
  • Name
    odd-skipped related 2
  • Synonyms
    5430409I15Rik, Osr2A, Osr2B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930813
    NCBI Gene: 107587
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:35296244-35303451 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 14.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    199 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930813
 protein coding gene Chr15:35296244-35303451 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021786
 protein coding gene Chr15:33662494-33669698 (+)
A/J MGP_AJ_G0021747
 protein coding gene Chr15:32389084-32396288 (+)
AKR/J MGP_AKRJ_G0021725
 protein coding gene Chr15:33239298-33246502 (+)
BALB/cJ MGP_BALBcJ_G0021753
 protein coding gene Chr15:32365311-32372511 (+)
C3H/HeJ MGP_C3HHeJ_G0021528
 protein coding gene Chr15:33229621-33236827 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022192
 protein coding gene Chr15:34927603-34936057 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019730
 protein coding gene Chr15:30231471-30238652 (+)
CAST/EiJ MGP_CASTEiJ_G0021044
 protein coding gene Chr15:33631984-33639224 (+)
CBA/J MGP_CBAJ_G0021497
 protein coding gene Chr15:36008846-36016049 (+)
DBA/2J MGP_DBA2J_G0021621
 protein coding gene Chr15:32188043-32195246 (+)
FVB/NJ MGP_FVBNJ_G0021599
 protein coding gene Chr15:31611762-31618964 (+)
LP/J MGP_LPJ_G0021690
 protein coding gene Chr15:33555306-33562510 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021624
 protein coding gene Chr15:39039589-39046793 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022215
 protein coding gene Chr15:33425034-33432237 (+)
PWK/PhJ MGP_PWKPhJ_G0020788
 protein coding gene Chr15:32223095-32230323 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020626
 protein coding gene Chr15:33110862-33118033 (+)
WSB/EiJ MGP_WSBEiJ_G0021100
 protein coding gene Chr15:33375446-33382655 (+)



Homology
more
  • Human Ortholog
    OSR2, odd-skipped related transciption factor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OSR2, odd-skipped related transciption factor 2
  • Links
    NCBI Gene ID: 116039
    neXtProt AC: NX_Q8N2R0
    UniProt: Q8N2R0

  • Chr Location
    8q22.2; chr8:98944403-98952104 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 5 genetic backgrounds
    38 phenotypes from multigenic genotypes
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display neonatal lethality, cleft of the secondary palate, and thickened tympanic rings.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1083
  • Tissues
    261
  • cDNA Data
    34
  • Literature Summary
    62
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107587 NCBI Gene Model | MGI Sequence Detail 7208 C57BL/6J ±  kb
    transcript NM_001368665 RefSeq | MGI Sequence Detail 1806 ZRU/MplStud  
    polypeptide Q91ZD1 UniProt | EBI | MGI Sequence Detail 312 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      Genomic 1
      cDNA 36
      Primer pair 8
      Other 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1918649
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 62
      Gene Ontology 10
      Phenotypes 57
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:349110 Zhang J, et al., Osr2 functions as a biomechanical checkpoint to aggravate CD8(+) T cell exhaustion in tumor. Cell. 2024 May 9;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory