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Csf2tm1Ard
Targeted Allele Detail
Summary
Symbol: Csf2tm1Ard
Name: colony stimulating factor 2 (granulocyte-macrophage); targeted mutation 1, Ashley R Dunn
MGI ID: MGI:1930997
Synonyms: CSF-2o, GM-, GM-CSF-
Gene: Csf2  Location: Chr11:54138097-54140493 bp, - strand  Genetic Position: Chr11, 32.13 cM
Alliance: Csf2tm1Ard page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:18747
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exons 1 and 2 and flanking intronic sequence was replaced by a LacZ gene, human beta globin gene 3' untranslated and poly(A) sequences and a neomycin cassette. (J:18747)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 130 assay results
In Structures Affected by this Mutation: 10 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Csf2 Mutation:  35 strains or lines available
References
Original:  J:18747 Stanley E, et al., Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology. Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5592-6
All:  57 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory