Vegfa<tm2Gne> Targeted Allele Detail MGI Mouse (MGI:1931048)

Vegfa^tm2Gne
Targeted Allele Detail

Summary

Symbol:	Vegfa^tm2Gne
Name:	vascular endothelial growth factor A; targeted mutation 2, Genentech
MGI ID:	MGI:1931048
Synonyms:	Vegf-A/loxP, VEGF^+f, VEGF^Flox, VEGF^lox, VEGFloxP, VEGFloxP(-)
Gene:	Vegfa Location: Chr17:46327919-46343295 bp, - strand Genetic Position: Chr17, 22.79 cM
Alliance:	Vegfa^tm2Gne page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:52793
Parent Cell Line:	GS1 (ES Cell)
Strain of Origin:	129/Sv

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: Insertion of a loxP-flanked neomycin cassette and a loxP site flanking exon 3. This mutation had no effect on the secretion of the protein. (J:52793)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	1 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	29 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Vegfa^tm2Gne

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Vegfa Mutation:	38 strains or lines available

References

Original:	J:52793 Gerber HP, et al., VEGF is required for growth and survival in neonatal mice. Development. 1999 Mar;126(6):1149-59
All:	148 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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