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Tac4 Gene Detail
Summary
  • Symbol
    Tac4
  • Name
    tachykinin 4
  • Synonyms
    hemokinin I (HK-1), PPT-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931130
    NCBI Gene: 93670
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr11:95152355-95160091 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 59.01 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    350 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931130
 protein coding gene Chr11:95152355-95160091 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018979
 protein coding gene Chr11:97452947-97460694 (+)
A/J MGP_AJ_G0018947
 protein coding gene Chr11:93522401-93530163 (+)
AKR/J MGP_AKRJ_G0018917
 protein coding gene Chr11:96413552-96421300 (+)
BALB/cJ MGP_BALBcJ_G0018920
 protein coding gene Chr11:93994162-94001896 (+)
C3H/HeJ MGP_C3HHeJ_G0018734
 protein coding gene Chr11:96538304-96546052 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019372
 protein coding gene Chr11:100516601-100524337 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017003
 protein coding gene Chr11:91007637-91015560 (+)
CAST/EiJ MGP_CASTEiJ_G0018288
 protein coding gene Chr11:97335501-97343189 (+)
CBA/J MGP_CBAJ_G0018705
 protein coding gene Chr11:104617694-104625462 (+)
DBA/2J MGP_DBA2J_G0018813
 protein coding gene Chr11:93095636-93103526 (+)
FVB/NJ MGP_FVBNJ_G0018802
 protein coding gene Chr11:92561736-92570344 (+)
LP/J MGP_LPJ_G0018883
 protein coding gene Chr11:98019424-98027142 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018829
 protein coding gene Chr11:104664557-104672310 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019412
 protein coding gene Chr11:96676921-96684657 (+)
PWK/PhJ MGP_PWKPhJ_G0018059
 protein coding gene Chr11:94017027-94024833 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017848
 protein coding gene Chr11:96361918-96369736 (+)
WSB/EiJ MGP_WSBEiJ_G0018337
 protein coding gene Chr11:96598492-96606258 (+)



Homology
more
  • Human Ortholog
    TAC4, tachykinin precursor 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAC4, tachykinin precursor 4
  • Synonyms
    EK, HK-1, HK1, PPT-C
  • Links
    NCBI Gene ID: 255061
    neXtProt AC: NX_Q86UU9
    UniProt: Q86UU9

  • Chr Location
    17q21.33; chr17:49838300-49848069 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased pro-B cells without an increase in mature B cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    21
  • cDNA Data
    4
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 93670 NCBI Gene Model | MGI Sequence Detail 7737 C57BL/6J ±  kb
transcript NM_053093 RefSeq | MGI Sequence Detail 1262 Not Specified  
polypeptide Q99N14 UniProt | EBI | MGI Sequence Detail 128 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    Genomic 2
    cDNA 4
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:2144537
References
more
  • Summaries
    All 41
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 17
  • Earliest
    J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
  • Latest
    J:342660 Nethander M, et al., An atlas of genetic determinants of forearm fracture. Nat Genet. 2023 Nov;55(11):1820-1830
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory