Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Cd19tm1(cre)Cgn
Name:	CD19 antigen; targeted mutation 1, University of Cologne
MGI ID:	MGI:1931143
Synonyms:	B-Cre, CD19-, Cd19cre, Cd19Cre, CD19-Cre, CD19-KO
Gene:	Cd19  Location: Chr7:126007622-126014061 bp, - strand  Genetic Position: Chr7, 69.01 cM, cytoband F3-F4
Alliance:	Cd19tm1(cre)Cgn page

Germline Transmission:	Earliest citation of germline transmission: J:27463
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Cd19tm1(cre)Cgn expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Cd19 (MGI:88319)   Mutation details: In-frame insertion of a cre recombinase gene into the first coding exon followed by an fFRT site flanked neomycin resistance gene cassette. A frameshift mutation was also introduced into exon 5. This allele expresses cre recombinase specifically in B lineage cells throughout development. (J:27463)

Activity:	Tissue activity of this recombinase allele
Driver:	Cd19 (mouse) Summary of all recombinase alleles driven by Cd19. Comparative matrix view of recombinase activities Alliance mouse Cd19 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	8 assay results 6 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

List all tumor models in MMHCdb carrying Cd19tm1(cre)Cgn

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 11 strains available      Cell Lines: 0 lines available
Carrying any Cd19 Mutation:	60 strains or lines available

Original:	J:27463 Rickert RC, et al., Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature. 1995 Jul 27;376(6538):352-5
All:	731 reference(s)