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Hdac9 Gene Detail
Summary
  • Symbol
    Hdac9
  • Name
    histone deacetylase 9
  • Synonyms
    D030072B18Rik, Hdac7b, HDRP, Mitr
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931221
    NCBI Gene: 79221
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:34097579-34967094 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 15.06 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    22701 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931221
 protein coding gene Chr12:34097579-34967094 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019680
 protein coding gene Chr12:32496427-32660535 (-)
A/J MGP_AJ_G0019646
 protein coding gene Chr12:31520546-31677586 (-)
AKR/J MGP_AKRJ_G0019617
 protein coding gene Chr12:32507996-32667289 (-)
BALB/cJ MGP_BALBcJ_G0019624
 protein coding gene Chr12:31700392-31858360 (-)
C3H/HeJ MGP_C3HHeJ_G0019428
 protein coding gene Chr12:32368368-32529275 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020071
 protein coding gene Chr12:33448956-33618644 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017696
 protein coding gene Chr12:30694633-30855699 (-)
CAST/EiJ MGP_CASTEiJ_G0018982
 protein coding gene Chr12:27439496-27608603 (-)
CBA/J MGP_CBAJ_G0019400
 protein coding gene Chr12:34524484-34693956 (-)
DBA/2J MGP_DBA2J_G0019513
 protein coding gene Chr12:31335782-31493795 (-)
FVB/NJ MGP_FVBNJ_G0019502
 protein coding gene Chr12:31084581-31243717 (-)
LP/J MGP_LPJ_G0019583
 protein coding gene Chr12:32556856-32719997 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019538
 protein coding gene Chr12:34195433-34382395 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020111
 protein coding gene Chr12:32005695-32166104 (-)
PWK/PhJ MGP_PWKPhJ_G0018749
 protein coding gene Chr12:26057527-26219204 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018538
 protein coding gene Chr12:26674106-26840275 (-)
WSB/EiJ MGP_WSBEiJ_G0019032
 protein coding gene Chr12:32244586-32412366 (-)



Homology
more
  • Human Ortholog
    HDAC9, histone deacetylase 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HDAC9, histone deacetylase 9
  • Synonyms
    ARCND4, HD7, HD7b, HD9, HDAC, HDAC7, HDAC7B, HDAC9B, HDAC9FL, HDRP, MITR
  • Links
    NCBI Gene ID: 9734
    neXtProt AC: NX_Q9UKV0
    UniProt: Q9UKV0

  • Chr Location
    7p21.1; chr7:18086825-19002416 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display age dependent cardiac hypertrophy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    839
  • Tissues
    53
  • cDNA Data
    13
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 79221 NCBI Gene Model | MGI Sequence Detail 869516 C57BL/6J ±  kb
    transcript NM_001271386 RefSeq | MGI Sequence Detail 8195 C57BL/6  
    polypeptide Q99N13 UniProt | EBI | MGI Sequence Detail 588 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 1
      cDNA 13
      Primer pair 8

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144976, MGI:3036283
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 21
      Gene Ontology 15
      Phenotypes 23
    • Earliest
      J:60199 Zhou X, et al., Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5. Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1056-61
    • Latest
      J:358297 Ahmadieh S, et al., Impact of housing temperature on adipose tissue HDAC9 expression and adipogenic differentiation in high fat-fed mice. Obesity (Silver Spring). 2024 Jan;32(1):107-119
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory