About   Help   FAQ
Dhx58 Gene Detail
Summary
  • Symbol
    Dhx58
  • Name
    DExH-box helicase 58
  • Synonyms
    B430001I08Rik, D11Lgp2e, LPG2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931560
    NCBI Gene: 80861
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100585710-100595097 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 63.52 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    268 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931560
 protein coding gene Chr11:100585710-100595165 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019164
 protein coding gene Chr11:103460401-103469767 (-)
A/J MGP_AJ_G0019132
 protein coding gene Chr11:99145736-99154928 (-)
AKR/J MGP_AKRJ_G0019101
 protein coding gene Chr11:102216738-102225931 (-)
BALB/cJ MGP_BALBcJ_G0019106
 protein coding gene Chr11:99632926-99642163 (-)
C3H/HeJ MGP_C3HHeJ_G0018915
 protein coding gene Chr11:102389979-102399331 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019555
 protein coding gene Chr11:106674820-106684229 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017181
 protein coding gene Chr11:96560695-96571784 (-)
CAST/EiJ MGP_CASTEiJ_G0018469
 protein coding gene Chr11:103366468-103375645 (-)
CBA/J MGP_CBAJ_G0018884
 protein coding gene Chr11:111128041-111137422 (-)
DBA/2J MGP_DBA2J_G0018996
 protein coding gene Chr11:98682395-98691710 (-)
FVB/NJ MGP_FVBNJ_G0018986
 protein coding gene Chr11:98220128-98229962 (-)
LP/J MGP_LPJ_G0019065
 protein coding gene Chr11:104020948-104031422 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019017
 protein coding gene Chr11:110712718-110722226 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019593
 protein coding gene Chr11:102541238-102551609 (-)
PWK/PhJ MGP_PWKPhJ_G0018232
 protein coding gene Chr11:99719575-99729478 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018024
 protein coding gene Chr11:102282848-102294005 (-)
WSB/EiJ MGP_WSBEiJ_G0018518
 protein coding gene Chr11:102528492-102539850 (-)



Homology
more
  • Human Ortholog
    DHX58, DExH-box helicase 58
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DHX58, DExH-box helicase 58
  • Synonyms
    D11LGP2, D11lgp2e, LGP2, RLR-3
  • Links
    NCBI Gene ID: 79132
    neXtProt AC: NX_Q96C10
    UniProt: Q96C10

  • Chr Location
    17q21.2; chr17:42101404-42112714 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 5 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to EMCV infection and decreased susceptibility to VSV infection. Mice homozygous for a different knock-out allele exhibit increased susceptibility to WNV infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    749
  • Tissues
    29
  • cDNA Data
    35
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017830 Ensembl Gene Model | MGI Sequence Detail 9388 C57BL/6J ±  kb
    transcript ENSMUST00000017974 Ensembl | MGI Sequence Detail 2412 Not Applicable  
    polypeptide ENSMUSP00000017974 Ensembl | MGI Sequence Detail 678 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000032742 ATP-dependent RNA helicase DHX58
      (term hierarchy)
    • EC
      3.6.4.13
    • InterPro Domains
      IPR001650 Helicase, C-terminal domain-like
      IPR014001 Helicase superfamily 1/2, ATP-binding domain
      IPR006935 Helicase/UvrB, N-terminal
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR041204 RIG-I-like receptor, C-terminal
      IPR038557 RIG-I-like receptor, C-terminal domain superfamily
      IPR021673 RIG-I-like receptor, C-terminal regulatory domain
      IPR051363 RIG-I-like Receptor (RLR) Helicase
    • GlyGen
      Q99J87 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 36

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1925936
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 1
      Gene Ontology 13
      Phenotypes 26
    • Earliest
      J:50799 Liu P, et al., Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11. Genetics. 1998 Nov;150(3):1155-68
    • Latest
      J:351312 Jia KW, et al., Interferon-alpha stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis. Mil Med Res. 2024 Apr 15;11(1):22
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory