Jag1<Slalom> Chemically induced Allele Detail MGI Mouse (MGI:1931798)

Jag1^Slalom
Chemically induced Allele Detail

Summary

Symbol:	Jag1^Slalom
Name:	jagged 1; slalom
MGI ID:	MGI:1931798
Synonyms:	Gena 158, Gena158, slalom, Slm
Gene:	Jag1 Location: Chr2:136923371-136958440 bp, - strand
Alliance:	Jag1^Slalom page

Mutation
origin

Strain of Origin:	BALB/cAnNCrl
Project Collection:	Harwell ENU Mutagenesis

Mutation
description

Allele Type:		Chemically induced (ENU)
Mutation:		Single point mutation
		Mutation details: A C to T missense mutation causes a proline to serine change at conserved codon 269 in the second epidermal growth factor (EGF)-like repeat. (J:63716, J:67728)
Inheritance:		Dominant

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Jag1 Mutation:	78 strains or lines available

Notes

This mutation was induced by ENU treatment of a BALB/cAnNCrl male mouse that was then mated with C3H/HeNCrl females. Mapping of the dominant mutation was achieved using IVF-generated backcross progeny of the founder male x C3H females. (J:63816, J:67728)

References

Original:	J:67728 Tsai H, et al., The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti. Hum Mol Genet. 2001 Mar 1;10(5):507-12
All:	4 reference(s)

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