Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Ccr1tm1Gao Name: C-C motif chemokine receptor 1; targeted mutation 1, Ji-Liang Gao MGI ID: MGI:1931850 Synonyms: CCR1- Gene: Ccr1  Location: Chr9:123762163-123768729 bp, - strand  Genetic Position: Chr9, 75.05 cM, cytoband F Alliance: Ccr1tm1Gao page

Ccr1tm1Gao/Ccr1tm1Gao and control mice underwent bile duct ligation or sham operation. Macrophage infiltration was determined by immunohistochemistry for F4/80 Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:41324
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced open reading frame sequences that correspond to 33% of the protein, from the third to the fifth transmembrane segment. Transcript was not detected in neutrophils of homozygous mutant animals. (J:41324)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

List all tumor models in MMHCdb carrying Ccr1tm1Gao

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 9 strains available      Cell Lines: 0 lines available
Carrying any Ccr1 Mutation:	40 strains or lines available

Original:	J:41324 Gao JL, et al., Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1. J Exp Med. 1997 Jun 2;185(11):1959-68
All:	59 reference(s)