Ncoa3<tm1Jxu> Targeted Allele Detail MGI Mouse (MGI:1931860)

Ncoa3^tm1Jxu
Targeted Allele Detail

Summary

Symbol:	Ncoa3^tm1Jxu
Name:	nuclear receptor coactivator 3; targeted mutation 1, Jianming Xu
MGI ID:	MGI:1931860
Synonyms:	AIB1^-, SRC-3-
Gene:	Ncoa3 Location: Chr2:165834557-165915162 bp, + strand Genetic Position: Chr2, 86.22 cM, cytoband H2-H4
Alliance:	Ncoa3^tm1Jxu page

Alveolar formation is reduced in the Ncoa3^tm1Jxu/Ncoa3^tm1Jxu mammary gland.

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:62724
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Mutation
description

Allele Type:		Targeted (Null/knockout, Reporter)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A TGK-neomycin resistance cassette replaced sequences spanning exon 2 through exon 13. The cassette introduced a lacZ sequence in frame with the endogenous promoter. The authors predict that the targeted allele would not produce a functional protein, but would produce a beta-galactosidase fusion protein controlled by the endogenous promoter. Western analysis did not detect wild-type protein in lactating mammary glands of homozygous mutant mice. (J:62724)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Ncoa3 Mutation:	233 strains or lines available

References

Original:	J:62724 Xu J, et al., The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6379-84
All:	37 reference(s)

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