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Dnajb1 Gene Detail
Summary
  • Symbol
    Dnajb1
  • Name
    DnaJ heat shock protein family (Hsp40) member B1
  • Synonyms
    0610007I11Rik, Hsp40
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931874
    NCBI Gene: 81489
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:84334822-84339282 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 40.22 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    182 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931874
 protein coding gene Chr8:84334804-84339282 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033835
 protein coding gene Chr8:84441966-84445719 (+)
A/J MGP_AJ_G0033818
 protein coding gene Chr8:81146676-81150425 (+)
AKR/J MGP_AKRJ_G0033744
 protein coding gene Chr8:83534295-83538048 (+)
BALB/cJ MGP_BALBcJ_G0033811
 protein coding gene Chr8:81243054-81246807 (+)
C3H/HeJ MGP_C3HHeJ_G0033521
 protein coding gene Chr8:84161421-84165170 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034331
 protein coding gene Chr8:87667947-87671674 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031273
 protein coding gene Chr8:74928281-74932002 (+)
CAST/EiJ MGP_CASTEiJ_G0032851
 protein coding gene Chr8:83551149-83555205 (+)
CBA/J MGP_CBAJ_G0033499
 protein coding gene Chr8:90815688-90819666 (+)
DBA/2J MGP_DBA2J_G0033652
 protein coding gene Chr8:80785993-80789742 (+)
FVB/NJ MGP_FVBNJ_G0033598
 protein coding gene Chr8:79697559-79701276 (+)
LP/J MGP_LPJ_G0033742
 protein coding gene Chr8:84556102-84559855 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033640
 protein coding gene Chr8:93312448-93316211 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034348
 protein coding gene Chr8:83508802-83512529 (+)
PWK/PhJ MGP_PWKPhJ_G0032555
 protein coding gene Chr8:79999356-80003128 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032392
 protein coding gene Chr8:82305520-82309264 (+)
WSB/EiJ MGP_WSBEiJ_G0032964
 protein coding gene Chr8:83913824-83918591 (+)



Homology
more
  • Human Ortholog
    DNAJB1, DnaJ heat shock protein family (Hsp40) member B1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNAJB1, DnaJ heat shock protein family (Hsp40) member B1
  • Synonyms
    Hdj1, Hsp40, HSPF1, RSPH16B, Sis1
  • Links
    NCBI Gene ID: 3337
    neXtProt AC: NX_P25685
    UniProt: P25685

  • Chr Location
    19p13.12; chr19:14514769-14560391 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    39 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Dnajb1
  • Incidental Mutations
    CvDC
  • Find Mice (IMSR)
    21 strains or lines available
Mice homozygous for a knock-out allele are viable, fertile, and overtly normal; however, homozygous null peritoneal macrophages display impaired thermotolerance in the early (but not in the late) phase after mild heat treatment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    43
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    754
  • Tissues
    38
  • cDNA Data
    16
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005483 Ensembl Gene Model | MGI Sequence Detail 4461 C57BL/6J ±  kb
transcript ENSMUST00000005620 Ensembl | MGI Sequence Detail 2996 Not Applicable  
polypeptide ENSMUSP00000005620 Ensembl | MGI Sequence Detail 340 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 16
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1915569
References
more
  • Summaries
    All 81
    Developmental Gene Expression 5
    Gene Ontology 9
    Phenotypes 39
  • Earliest
    J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
  • Latest
    J:348117 Okuma H, et al., N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on alpha-dystroglycan and prevents muscular dystrophy. Elife. 2023 Feb 1;12
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory