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Nkx2-2tm1Jlr
Targeted Allele Detail
Summary
Symbol: Nkx2-2tm1Jlr
Name: NK2 homeobox 2; targeted mutation 1, John L R Rubenstein
MGI ID: MGI:1932100
Synonyms: Nkx2.2-
Gene: Nkx2-2  Location: Chr2:147019466-147036163 bp, - strand  Genetic Position: Chr2, 72.63 cM, cytoband H
Alliance: Nkx2-2tm1Jlr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:48576
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Insertion of a PGK-neomycin resistance cassette replaced exons 1 and 2. Immunohistochemical studies of pancreas and CNS did not detect protein in homozygous mutant mice. (J:48576)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 37 assay results
2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx2-2 Mutation:  14 strains or lines available
References
Original:  J:48576 Sussel L, et al., Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development. 1998 Jun;125(12):2213-21
All:  49 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory