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Ankrd17 Gene Detail
Summary
  • Symbol
    Ankrd17
  • Name
    ankyrin repeat domain 17
  • Synonyms
    4933425K22Rik, A130069E23Rik, Gtar, mKIAA0697
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932101
    NCBI Gene: 81702
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:90375025-90514436 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 44.32 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2555 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932101
 protein coding gene Chr5:90375025-90517133 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029719
 protein coding gene Chr5:91291007-91436055 (-)
A/J MGP_AJ_G0029685
 protein coding gene Chr5:87681026-87821945 (-)
AKR/J MGP_AKRJ_G0029631
 protein coding gene Chr5:90538167-90684001 (-)
BALB/cJ MGP_BALBcJ_G0029695
 protein coding gene Chr5:88581125-88721289 (-)
C3H/HeJ MGP_C3HHeJ_G0029418
 protein coding gene Chr5:90953408-91094544 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030149
 protein coding gene Chr5:94957079-95102959 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027385
 protein coding gene Chr5:83413677-83554146 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0029388
 protein coding gene Chr5:98194110-98347351 (-)
DBA/2J MGP_DBA2J_G0029532
 protein coding gene Chr5:87760983-87905121 (-)
FVB/NJ MGP_FVBNJ_G0029491
 protein coding gene Chr5:86626292-86764461 (-)
LP/J MGP_LPJ_G0029620
 protein coding gene Chr5:91681656-91822137 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029520
 protein coding gene Chr5:103174622-103348021 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030183
 protein coding gene Chr5:90075010-90213695 (-)
PWK/PhJ MGP_PWKPhJ_G0028547
 protein coding gene Chr5:86818484-86961088 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028382
 protein coding gene Chr5:89491640-89630428 (-)
WSB/EiJ MGP_WSBEiJ_G0028907
 protein coding gene Chr5:90533071-90677619 (-)



Homology
more
  • Human Ortholog
    ANKRD17, ankyrin repeat domain 17
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANKRD17, ankyrin repeat domain 17
  • Synonyms
    CAGS, GTAR, MASK2, NY-BR-16
  • Links
    NCBI Gene ID: 26057
    neXtProt AC: NX_O75179
    UniProt: O75179

  • Chr Location
    4q13.3; chr4:73073376-73258798 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display embryonic lethality during organogenesis with hemorrhages, impaired vascular smooth muscle cell development, impaired vascular integrity, and growth retardation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    818
  • Tissues
    55
  • cDNA Data
    24
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000055204 Ensembl Gene Model | MGI Sequence Detail 139412 C57BL/6J ±  kb
    transcript ENSMUST00000014421 Ensembl | MGI Sequence Detail 10458 Not Applicable  
    polypeptide ENSMUSP00000014421 Ensembl | MGI Sequence Detail 2603 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000004043 ankyrin repeat domain-containing protein 17
      (term hierarchy)
    • InterPro Domains
      IPR002110 Ankyrin repeat
      IPR051631 Ankyrin repeat and KH/SAM domain-containing protein
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR047375 Ankyrin repeat domain-containing protein 17, type I K homology domain
      IPR004087 K Homology domain
      IPR004088 K Homology domain, type 1
      IPR036612 K Homology domain, type 1 superfamily
    • GlyGen
      Q99NH0 42 sites, 6 N-linked glycans (7 sites), 1 O-linked glycan (35 sites)
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 31
      Primer pair 4

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:1918421, MGI:2140727, MGI:2140756, MGI:2141077, MGI:2444962
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 8
      Gene Ontology 8
      Phenotypes 20
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:310414 Hung CH, et al., A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL Sustaining the Erythropoiesis. Int J Mol Sci. 2021 Jul 27;22(15)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory